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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2(1),26-35;2009
Original Article
Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: a
meta-analysis
Ming Yin, Dongfeng Tan, Qingyi Wei
Departments of 1Epidemiology and 2Pathology, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd,
Houston, TX 77030, USA.
Received December 27, 2008; accepted January, 2009; available online January, 2009
Abstract: To summarize data on the role of X-ray repair cross-complementing group 1 (XRCC1) common genetic variants in
susceptibility to esophageal cancer (EC), we performed a meta-analysis including 11 eligible publications with 3,306 patients and
6,852 controls for Arg399Gln and 832 patients and 1,418 controls for Arg194Trp. Overall, the variant Gln399 allele was not associated
with EC risk, compared with the Arg399 allele in the populations included in the analysis. However, stratified analysis revealed that
Gln399 allele was associated with an increased EC risk among Chinese populations in a recessive model (OR, 1.33; 95% CI
1.01-1.76; fixed effects) and by homozygote contrast (OR, 1.35; 95% CI 1.01-1.81), particularly for the tumor histology of squamous cell
carcinoma (OR, 1.34; 95% CI 1.03-1.73 for the recessive model) and (OR, 1.34; 95% CI 1.02-1.76 for the homozygote contrast). There
was no apparent effect of the Trp194 allele, compared to the Arg194 allele, on the EC risk in all analyses. These results suggest that
XRCC1 Arg399Gln polymorphism may be a potential biomarker of EC susceptibility in Chinese populations, particularly for squamous
cell carcinoma. Further larger studies with multi-ethnic populations are required to further assess the association between XRCC1
polymorphisms and EC risk. (IJCEM812003).
Key Words: Esophageal cancer, genetic polymorphism, meta-analysis, molecular epidemiology
Full Text PDF
Address all correspondence to:
Qingyi Wei, MD, PhD
Department of Epidemiology
The University of Texas, M. D. Anderson Cancer Center
1515 Holcombe Blvd, Unit 1365
Houston, TX 77030
USA
Tel: 713-792-3020
Fax: 713-563-0999
E-mail: qwei@mdanderson.org
Original Article
Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: a
meta-analysis
Ming Yin, Dongfeng Tan, Qingyi Wei
Departments of 1Epidemiology and 2Pathology, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd,
Houston, TX 77030, USA.
Received December 27, 2008; accepted January, 2009; available online January, 2009
Abstract: To summarize data on the role of X-ray repair cross-complementing group 1 (XRCC1) common genetic variants in
susceptibility to esophageal cancer (EC), we performed a meta-analysis including 11 eligible publications with 3,306 patients and
6,852 controls for Arg399Gln and 832 patients and 1,418 controls for Arg194Trp. Overall, the variant Gln399 allele was not associated
with EC risk, compared with the Arg399 allele in the populations included in the analysis. However, stratified analysis revealed that
Gln399 allele was associated with an increased EC risk among Chinese populations in a recessive model (OR, 1.33; 95% CI
1.01-1.76; fixed effects) and by homozygote contrast (OR, 1.35; 95% CI 1.01-1.81), particularly for the tumor histology of squamous cell
carcinoma (OR, 1.34; 95% CI 1.03-1.73 for the recessive model) and (OR, 1.34; 95% CI 1.02-1.76 for the homozygote contrast). There
was no apparent effect of the Trp194 allele, compared to the Arg194 allele, on the EC risk in all analyses. These results suggest that
XRCC1 Arg399Gln polymorphism may be a potential biomarker of EC susceptibility in Chinese populations, particularly for squamous
cell carcinoma. Further larger studies with multi-ethnic populations are required to further assess the association between XRCC1
polymorphisms and EC risk. (IJCEM812003).
Key Words: Esophageal cancer, genetic polymorphism, meta-analysis, molecular epidemiology
Full Text PDF
Address all correspondence to:
Qingyi Wei, MD, PhD
Department of Epidemiology
The University of Texas, M. D. Anderson Cancer Center
1515 Holcombe Blvd, Unit 1365
Houston, TX 77030
USA
Tel: 713-792-3020
Fax: 713-563-0999
E-mail: qwei@mdanderson.org
