IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Clin Exp Med 2013;6(1):1-15

Original Article
Targeting mitochondrial dysfunction in the treatment of Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – a clinical audit

Sarah Myhill, Norman E Booth, John McLaren-Howard

Sarah Myhill Ltd, Llangunllo, Powys UK; Department of Physics and Mansfield College, University of Oxford, Oxford UK; Acumen,
Tiverton, Devon UK

Received July 10, 2012; Accepted October 11, 2012; Epub November 20, 2012; Published January 1, 2013

Abstract: We report on an audit of 138 ME/CFS patients who attended a private practice and took the ATP Profile biomedical test. The
results revealed that all of these patients had measureable mitochondrial dysfunction. A basic treatment regime, based on 1) eating
the evolutionary correct stone-age diet, 2) ensuring optimum hours of good quality sleep, 3) taking a standard package of nutritional
supplements, and 4) getting the right balance between work and rest, was recommended for all patients. Additions to the basic regime
were tailored for each patient according to the results of the ATP Profile and additional nutritional tests and clues from the clinical
history. Mitochondrial function is typically impaired in two ways: substrate or co-factor deficiency, and inhibition by chemicals,
exogenous or endogenous. For the former, additional nutrients are recommended where there is a deficiency, and for the latter,
improvement of anti-oxidant status and selective chelation therapy or far-infrared saunas are appropriate. We show case histories of
nine patients who have taken the ATP Profile on three or four occasions, and a before-and-after treatment summary of the 34 patients
who have had at least two ATP Profile tests separated by some months. Finally, we summarize the results for the 30 patients who
followed all aspects of the treatment regime and compare them with the 4 patients who were lax on two or more aspects of the
treatment regime. All patients who followed the treatment regime improved in mitochondrial function by on average a factor of 4.

Keywords: Myalgic encephalomyelitis, Chronic fatigue syndrome, Mitochondrial dysfunction, Adenosine triphosphate (ATP), Oxidative
phosphorylation, Cellular energetics, Nutrition

Address all correspondence to:
Dr. Norman E Booth
‘Applegate’, Orchard Lane
East Hendred, Wantage
OX12 8JW, UK.
Tel: +44 1235 833486
E-mail: n.booth1@physics.ox.ac.uk