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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(1):92-95
Case Report
Myxofibrosarcoma with metastasis to the lungs, pleura, and mediastinum: a case
report and review of literature
Catherine Hambleton, Salem Noureldine, Farrukh Gill, Krzysztof Moroz, Emad Kandil
Department of Surgery, Division of Endocrine and Oncological Surgery Tulane University School of Medicine, New Orleans, LA;
Department of Pathology, Tulane University School of Medicine, New Orleans, LA, USA.
Received December 13, 2011; accepted January 11, 2012; Epub January 15, 2012; Published January 31, 2012
Abstract: Myxofibrosarcoma is a common connective tissue neoplasm of malignant fibrocytes in a myxoid matrix favoring the
extremities. Like many other tumors of connective tissue, soft tissue sarcoma exhibits high recurrence rates but is rarely known to
metastasize. We present a patient with myxofibrosarcoma of the hand with metastases to the lungs, pleura, and mediastinum. The
mediastinal metastasis presented clinically with gastrointestinal symptoms due to compression of the gastroesophageal junction. To
our knowledge, this is the first report of metastatic myxofibrosarcoma of the hand and also the first report of metastatic
myxofibrosarcoma to mediastinal lymph nodes at the level of the gastroesophageal junction. We also performed a comprehensive
literature review of metastatic myxofibrosarcoma. (IJCEM1112006).
Keywords: Myxofibrosarcoma, soft tissue sarcoma
Address all correspondence to:
Dr. Emad Kandil
Department of Surgery,
Tulane University School of Medicine
1430 Tulane Avenue, Room 8510 (Box SL-22)
New Orleans, LA 70112, USA.
Tel: (504) 988-7520; Fax: (504) 988-4762
E-mail: ekandil@tulane.edu
Case Report
Myxofibrosarcoma with metastasis to the lungs, pleura, and mediastinum: a case
report and review of literature
Catherine Hambleton, Salem Noureldine, Farrukh Gill, Krzysztof Moroz, Emad Kandil
Department of Surgery, Division of Endocrine and Oncological Surgery Tulane University School of Medicine, New Orleans, LA;
Department of Pathology, Tulane University School of Medicine, New Orleans, LA, USA.
Received December 13, 2011; accepted January 11, 2012; Epub January 15, 2012; Published January 31, 2012
Abstract: Myxofibrosarcoma is a common connective tissue neoplasm of malignant fibrocytes in a myxoid matrix favoring the
extremities. Like many other tumors of connective tissue, soft tissue sarcoma exhibits high recurrence rates but is rarely known to
metastasize. We present a patient with myxofibrosarcoma of the hand with metastases to the lungs, pleura, and mediastinum. The
mediastinal metastasis presented clinically with gastrointestinal symptoms due to compression of the gastroesophageal junction. To
our knowledge, this is the first report of metastatic myxofibrosarcoma of the hand and also the first report of metastatic
myxofibrosarcoma to mediastinal lymph nodes at the level of the gastroesophageal junction. We also performed a comprehensive
literature review of metastatic myxofibrosarcoma. (IJCEM1112006).
Keywords: Myxofibrosarcoma, soft tissue sarcoma
Address all correspondence to:
Dr. Emad Kandil
Department of Surgery,
Tulane University School of Medicine
1430 Tulane Avenue, Room 8510 (Box SL-22)
New Orleans, LA 70112, USA.
Tel: (504) 988-7520; Fax: (504) 988-4762
E-mail: ekandil@tulane.edu
