 | |  | |  | |  | |  | |  | |  | |  |
| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(1):44-49
Original Article
Curcumin protects against intracellular amyloid toxicity in rat primary neurons
Jelina Ye, Yan Zhang
Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking
University, Beijing, 100871, China; Department of Neurology, Havikstraat 3, 6541 PL Nijmegen, Netherlands
Received December 6, 2011; accepted December 29, 2011; Epub January 15, 2012; Published January 31, 2012
Abstract: To investigate whether curcumin is protective against intracellular amyloid β (Aβ) toxicity, different concentrations of curcumin
were applied to with intracellular Aβ in rat primary hippocampal neurons in culture. We find that at low dosages, curcumin effectively
inhibits intracellular Aβ toxicity. Reactive oxidative species (ROS) is involved in mediating intracellular Aβ toxicity and possibly curcumin
protection. Our results indicate that oxidative stress may mediate cell death induced by intracellular Aβ in neurons. (IJCEM1112004).
Keywords: Amyloid, curcumin, ROS, toxicity, Alzheimer’s disease
Address all correspondence to:
Dr. Yan Zhang
College of Life Sciences
Room 219, Peking University
Beijing, 100871, China.
Tel: 86-10-62754880; Fax: 86-10-62751526
E-mail: yanzhang@pku.edu.cn
Original Article
Curcumin protects against intracellular amyloid toxicity in rat primary neurons
Jelina Ye, Yan Zhang
Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking
University, Beijing, 100871, China; Department of Neurology, Havikstraat 3, 6541 PL Nijmegen, Netherlands
Received December 6, 2011; accepted December 29, 2011; Epub January 15, 2012; Published January 31, 2012
Abstract: To investigate whether curcumin is protective against intracellular amyloid β (Aβ) toxicity, different concentrations of curcumin
were applied to with intracellular Aβ in rat primary hippocampal neurons in culture. We find that at low dosages, curcumin effectively
inhibits intracellular Aβ toxicity. Reactive oxidative species (ROS) is involved in mediating intracellular Aβ toxicity and possibly curcumin
protection. Our results indicate that oxidative stress may mediate cell death induced by intracellular Aβ in neurons. (IJCEM1112004).
Keywords: Amyloid, curcumin, ROS, toxicity, Alzheimer’s disease
Address all correspondence to:
Dr. Yan Zhang
College of Life Sciences
Room 219, Peking University
Beijing, 100871, China.
Tel: 86-10-62754880; Fax: 86-10-62751526
E-mail: yanzhang@pku.edu.cn
