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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(1):72-79
Original Article
GC Glu416Asp and Thr420Lys polymorphisms contribute to gastrointestinal cancer
susceptibility in a Chinese population
Liqing Zhou, Xiaojiao Zhang, Xuechao Chen, Li Liu, Chao Lu, Xiaohu Tang, Juan Shi, Meng Li, Mo Zhou, Zhouwei Zhang, Lingchen
Xiao, Ming Yang
Department of Radiation Oncology, Huaian No. 2 Hospital, Huaian, Jiangsu Province, China; College of Life Science and Technology,
Beijing University of Chemical Technology, Beijing, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong
Academy of Medical Science, Jinan, Shandong, China
Received November 22, 2011; accepted January 12, 2012; Epub January 15, 2012; Published January 31, 2012
Abstract: Vitamin D has potent anticancer properties, especially against gastrointestinal cancers. Group-specific component (GC), a
key member of vitamin D pathway proteins, could bind to and transport vitamin D to target organs. As a polymorphic protein, two
common coding single nucleotide polymorphisms (SNP) [Glu416Asp (rs7041) and Thr420Lys (rs4588)] were identified in its gene.
These SNPs have been associated to circulating vitamin D levels and several cancer risks in different populations. However, there is
no report on their role in gastrointestinal cancer development among Chinese to date. Therefore, we examined the association
between these variants and risk of gastrointestinal cancers in a case-control cohort including 964 patients with four gastrointestinal
cancers (hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer) and 1187 controls. Odds ratios and 95%
confidence intervals were estimated by logistic regression. We found that GC Thr420Lys polymorphism has significant impact on the
risk of developing gastrointestinal cancers, especially colorectal cancer. Additionally, subjects who carrying GC Asp416-Lys420
haplotype, which contains the at-risk 420Lys allele, also showed significantly increased risk to develop gastrointestinal cancers. In
conclusion, our study demonstrated that common genetic variants and haplotypes in GC may influence individual susceptibility to
gastrointestinal cancers in Chinese population. (IJCEM1111005).
Keywords: Group-specific component, single nucleotide polymorphism, gastrointestinal cancer, susceptibility
Address all correspondence to:
Dr. Ming Yang
College of Life Science and Technology
Beijing University of Chemical Technology
P. O. Box 53, Beijing 100029, China.
Tel: 86-10-64447747; Fax: 86-10-64437610
E-mail: yangm@mail.buct.edu.cn
Original Article
GC Glu416Asp and Thr420Lys polymorphisms contribute to gastrointestinal cancer
susceptibility in a Chinese population
Liqing Zhou, Xiaojiao Zhang, Xuechao Chen, Li Liu, Chao Lu, Xiaohu Tang, Juan Shi, Meng Li, Mo Zhou, Zhouwei Zhang, Lingchen
Xiao, Ming Yang
Department of Radiation Oncology, Huaian No. 2 Hospital, Huaian, Jiangsu Province, China; College of Life Science and Technology,
Beijing University of Chemical Technology, Beijing, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong
Academy of Medical Science, Jinan, Shandong, China
Received November 22, 2011; accepted January 12, 2012; Epub January 15, 2012; Published January 31, 2012
Abstract: Vitamin D has potent anticancer properties, especially against gastrointestinal cancers. Group-specific component (GC), a
key member of vitamin D pathway proteins, could bind to and transport vitamin D to target organs. As a polymorphic protein, two
common coding single nucleotide polymorphisms (SNP) [Glu416Asp (rs7041) and Thr420Lys (rs4588)] were identified in its gene.
These SNPs have been associated to circulating vitamin D levels and several cancer risks in different populations. However, there is
no report on their role in gastrointestinal cancer development among Chinese to date. Therefore, we examined the association
between these variants and risk of gastrointestinal cancers in a case-control cohort including 964 patients with four gastrointestinal
cancers (hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer) and 1187 controls. Odds ratios and 95%
confidence intervals were estimated by logistic regression. We found that GC Thr420Lys polymorphism has significant impact on the
risk of developing gastrointestinal cancers, especially colorectal cancer. Additionally, subjects who carrying GC Asp416-Lys420
haplotype, which contains the at-risk 420Lys allele, also showed significantly increased risk to develop gastrointestinal cancers. In
conclusion, our study demonstrated that common genetic variants and haplotypes in GC may influence individual susceptibility to
gastrointestinal cancers in Chinese population. (IJCEM1111005).
Keywords: Group-specific component, single nucleotide polymorphism, gastrointestinal cancer, susceptibility
Address all correspondence to:
Dr. Ming Yang
College of Life Science and Technology
Beijing University of Chemical Technology
P. O. Box 53, Beijing 100029, China.
Tel: 86-10-64447747; Fax: 86-10-64437610
E-mail: yangm@mail.buct.edu.cn
