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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(1):87-91
Case Report
Osseous metastasis of cutaneous squamous cell carcinoma treated successfully
with oxaliplatin, tegafur and leucovorin combination chemotherapy: a case report
Hong-wei Xu, Feng Ren, Wei Chen, Ying-jie Wang, Jin Chen, Zhi-hui Xie, Jin-hu Yang, Jian-jun Chu, Xu-yang You
The Fourth Affiliated Hospital of Soochow University, the Fourth People’s Hospital of Wuxi, 200 Huihe Road, Wuxi 214062, Jiangsu, P.R.
China
Received October 29, 2011; accepted November 26, 2011; Epub January 15, 2012; Published January 31, 2012
Abstract: Bone metastasis from cutaneous squamous cell carcinoma (SCC) is rare. We report a case of cutaneous SCC which was
diagnosed by the presence of bone metastasis and treated with combination chemotherapy. A 53 year male had tissue contusion and
persistent ulcer in the multiple regions of body for about 30 years and treat with Chinese Herbal Drugs in several hospitals, however,
did not thorough cure. He was referred to our hospital for a dermatological examination in March 2009. Excisional biopsy and positron
emission tomography-computed tomography (PET-CT) scan showed an invasive cutaneous SCC concomitant bone metastasis.
Surgical treatment is limited, because of multiple cancerous ulcer and metastatic spreading. Therefore, we proceed to treat with
oxaliplatin, tegafur and leucovorin (LV) combination chemotherapy and other adjuvant therapy. About 5 months following chemotherapy,
the general situation of the patient was improved. Further cycle of chemotherapy resulted in complete disappearance of the tumor
masses (confirmed by PET-CT). So far, there was no evidence of local recurrence or distant metastasis. This report indicates that the
combination chemotherapy of oxaliplatin, tegafur and LV seems to have a considerable therapeutic effect for cutaneous SCC
concomitant malignant bone metastasis. (IJCEM1110009).
Keywords: Cutaneous squamous cell carcinoma, bone metastasis, chemotherapy, PET-CT
Address all correspondence to:
Hongwei Xu, MD, PhD
Department of General Surgery
The Fourth Affiliated Hospital of Soochow University
Jiangsu University
P. R. China
Tel: +86-13361809853;
Fax: +86-0510-85800200;
E-mail:xuhongwei@ymail.com
Case Report
Osseous metastasis of cutaneous squamous cell carcinoma treated successfully
with oxaliplatin, tegafur and leucovorin combination chemotherapy: a case report
Hong-wei Xu, Feng Ren, Wei Chen, Ying-jie Wang, Jin Chen, Zhi-hui Xie, Jin-hu Yang, Jian-jun Chu, Xu-yang You
The Fourth Affiliated Hospital of Soochow University, the Fourth People’s Hospital of Wuxi, 200 Huihe Road, Wuxi 214062, Jiangsu, P.R.
China
Received October 29, 2011; accepted November 26, 2011; Epub January 15, 2012; Published January 31, 2012
Abstract: Bone metastasis from cutaneous squamous cell carcinoma (SCC) is rare. We report a case of cutaneous SCC which was
diagnosed by the presence of bone metastasis and treated with combination chemotherapy. A 53 year male had tissue contusion and
persistent ulcer in the multiple regions of body for about 30 years and treat with Chinese Herbal Drugs in several hospitals, however,
did not thorough cure. He was referred to our hospital for a dermatological examination in March 2009. Excisional biopsy and positron
emission tomography-computed tomography (PET-CT) scan showed an invasive cutaneous SCC concomitant bone metastasis.
Surgical treatment is limited, because of multiple cancerous ulcer and metastatic spreading. Therefore, we proceed to treat with
oxaliplatin, tegafur and leucovorin (LV) combination chemotherapy and other adjuvant therapy. About 5 months following chemotherapy,
the general situation of the patient was improved. Further cycle of chemotherapy resulted in complete disappearance of the tumor
masses (confirmed by PET-CT). So far, there was no evidence of local recurrence or distant metastasis. This report indicates that the
combination chemotherapy of oxaliplatin, tegafur and LV seems to have a considerable therapeutic effect for cutaneous SCC
concomitant malignant bone metastasis. (IJCEM1110009).
Keywords: Cutaneous squamous cell carcinoma, bone metastasis, chemotherapy, PET-CT
Address all correspondence to:
Hongwei Xu, MD, PhD
Department of General Surgery
The Fourth Affiliated Hospital of Soochow University
Jiangsu University
P. R. China
Tel: +86-13361809853;
Fax: +86-0510-85800200;
E-mail:xuhongwei@ymail.com
