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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(1):50-55
Original Article
Blood cell counts and their correlation with creatine kinase and C-reactive protein in
patients with acute myocardial infarction
Haseeb A Khan, Abdullah S Alhomida, Samia H Sobki, Abdulrahman Al Moghairi, Hatim EL Koronki
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; Division of Clinical Biochemistry,
Department of Pathology, Armed Forces Hospital, Riyadh, Saudi Arabia; Department of Adult Cardiology, Prince Sultan Cardiac Center,
Riyadh, Saudi Arabia
Received October 18, 2011; accepted December 2, 2011; Epub January 15, 2012; Published January 31, 2012
Abstract: This study reports differential blood cells counts and their correlations with creatine kinase (CK) and C-reactive protein (CRP)
levels in acute myocardial infarction (AMI) patients and normal subjects. Peripheral blood samples were obtained from all 39 AMI
patients and 35 controls for blood cell counts and CK and CRP analyses. Total WBC, WBC fractions (lymphocytes, monocytes,
neutrophils, eosinophils and basophils), RBC and platelets were measured with an automated hematology analyzer. The results
showed a significant increase in total WBC (8.688 Í 109/L versus 6.148 Í 109/L), monocytes (1.271 versus 0.497 Í 109/L), and
neutrophils (8.367 versus 3.223 Í 109/L) counts in AMI patients than controls. The RBC count was significantly less in AMI patients
(4.638 Í 1012/L) as compared to controls (5.105 Í 1012/L). However, there was no significant difference in lymphocytes, eosinophils,
basophils and platelet counts between AMI patients and controls. Both, serum CK (215.38 ± 43.15 versus 100.82 ± 8.86 U/L) and CRP
(29.49 ± 7.61 versus 3.48 ± 0.60 mg/L) were significantly higher in AMI patients as compared to controls. Age of the subjects was
neither correlated with blood cell counts nor CK indicating the validity of these markers irrespective of patient age. A significant
correlation was observed between WBC counts and CK (R = 0.242, P = 0.041) as well as CRP (R = 0.416, P = 0.000). In conclusion,
this study clearly showed significant increase in total and differential leukocyte counts indicating a pro-inflammatory cascade in AMI
patients. A significant correlation between WBC counts and CK or CRP levels suggest a possible biomarker value of WBC for a quick
prediction of both myocardial necrosis and inflammation in AMI patients. (IJCEM1110005)
Keywords: Acute myocardial infarction, blood cells count, creatine kinase, inflammation, biomarker
Address all correspondence to:
Dr. Haseeb A Khan
Department of Biochemistry
College of Science
Bld 5, Rm 1B20, King Saud University
P.O. Box 2455, Riyadh 11451, Saudi Arabia.
E-mail: khan_haseeb@yahoo.com, haseeb@ksu.edu.sa
Original Article
Blood cell counts and their correlation with creatine kinase and C-reactive protein in
patients with acute myocardial infarction
Haseeb A Khan, Abdullah S Alhomida, Samia H Sobki, Abdulrahman Al Moghairi, Hatim EL Koronki
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; Division of Clinical Biochemistry,
Department of Pathology, Armed Forces Hospital, Riyadh, Saudi Arabia; Department of Adult Cardiology, Prince Sultan Cardiac Center,
Riyadh, Saudi Arabia
Received October 18, 2011; accepted December 2, 2011; Epub January 15, 2012; Published January 31, 2012
Abstract: This study reports differential blood cells counts and their correlations with creatine kinase (CK) and C-reactive protein (CRP)
levels in acute myocardial infarction (AMI) patients and normal subjects. Peripheral blood samples were obtained from all 39 AMI
patients and 35 controls for blood cell counts and CK and CRP analyses. Total WBC, WBC fractions (lymphocytes, monocytes,
neutrophils, eosinophils and basophils), RBC and platelets were measured with an automated hematology analyzer. The results
showed a significant increase in total WBC (8.688 Í 109/L versus 6.148 Í 109/L), monocytes (1.271 versus 0.497 Í 109/L), and
neutrophils (8.367 versus 3.223 Í 109/L) counts in AMI patients than controls. The RBC count was significantly less in AMI patients
(4.638 Í 1012/L) as compared to controls (5.105 Í 1012/L). However, there was no significant difference in lymphocytes, eosinophils,
basophils and platelet counts between AMI patients and controls. Both, serum CK (215.38 ± 43.15 versus 100.82 ± 8.86 U/L) and CRP
(29.49 ± 7.61 versus 3.48 ± 0.60 mg/L) were significantly higher in AMI patients as compared to controls. Age of the subjects was
neither correlated with blood cell counts nor CK indicating the validity of these markers irrespective of patient age. A significant
correlation was observed between WBC counts and CK (R = 0.242, P = 0.041) as well as CRP (R = 0.416, P = 0.000). In conclusion,
this study clearly showed significant increase in total and differential leukocyte counts indicating a pro-inflammatory cascade in AMI
patients. A significant correlation between WBC counts and CK or CRP levels suggest a possible biomarker value of WBC for a quick
prediction of both myocardial necrosis and inflammation in AMI patients. (IJCEM1110005)
Keywords: Acute myocardial infarction, blood cells count, creatine kinase, inflammation, biomarker
Address all correspondence to:
Dr. Haseeb A Khan
Department of Biochemistry
College of Science
Bld 5, Rm 1B20, King Saud University
P.O. Box 2455, Riyadh 11451, Saudi Arabia.
E-mail: khan_haseeb@yahoo.com, haseeb@ksu.edu.sa
