 | |  | |  | |  | |  | |  | |  | |  |
| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2(4):348-353;2009.
Original Article
The effects of Fhit on tumorigenesis after multi-exposure
to low dose radiation
Xiaoyan Yu, Lin Lu, Siyuan Wen, Ya Wang
1Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA;
2Department of Experimental Phamacology and Toxicology, School of Pharmacy, Jilin University, Changchun,
130021, China; 3Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA;
4Current address: Beijing Institute of Radiation Medicine, Beijing 100850, China.
Received November 16, 2009; accepted November 18, 2009; available online November 22, 2009
Abstract: Low-dose (< 0.1 Gy) radiation could reduce high-dose induced damage including tumorigenesis. However, it remains
unclear whether multi-exposure to low-dose radiation at a high dose rate has any risk for increasing tumorigenesis, and whether Fhit
plays any role in the process. The purpose of this study is to investigate the effects of multi-exposure to low-dose radiation at a high
dose rate on tumorigenesis, and the role of Fhit in it. We irradiated Fhit+/+ and Fhit-/- mice with 1 Gy/1 or 0.1 Gy x 10 exposures at a
dose rate of 1 Gy/min, sacrificed the mice at 1.5 years after radiation and observed multi-organ tumorigenesis. The results showed that
although the spontaneous tumorigenesis in these mice was relatively high, 1 Gy/1-exposure dramatically increased the tumorigenesis
including lung and liver tumor. Fhit-/- mice showed more tumorigenesis than Fhit+/+ mice after 1 Gy/1- exposure. However, 0.1 Gy x 10
exposures did not increase tumorigenesis, and there was no statistical difference in tumorigenesis between Fhit+/+ mice and Fhit-/-
mice following 0.1 Gy x 10 exposures. Our results suggest that 0.1 Gy, even after multiple exposures, does not increase tumorigenesis,
and Fhit could prevent high-dose radiation-induced tumors but has no effect in a low-dose environment. (IJCEM911005).
Key words: Fhit, low dose, ionizing radiation, tumorigenesis
Full Text PDF
Address all correspondence to:
Ya Wang, PhD,
Emory University,
1365 Clifton Rd, NE
Atlanta, GA 30033, USA
Tel: (404) 778-1832, Fax: (404) 778-1750
E-mail: yawang@radonc.emory.org
Original Article
The effects of Fhit on tumorigenesis after multi-exposure
to low dose radiation
Xiaoyan Yu, Lin Lu, Siyuan Wen, Ya Wang
1Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA;
2Department of Experimental Phamacology and Toxicology, School of Pharmacy, Jilin University, Changchun,
130021, China; 3Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA;
4Current address: Beijing Institute of Radiation Medicine, Beijing 100850, China.
Received November 16, 2009; accepted November 18, 2009; available online November 22, 2009
Abstract: Low-dose (< 0.1 Gy) radiation could reduce high-dose induced damage including tumorigenesis. However, it remains
unclear whether multi-exposure to low-dose radiation at a high dose rate has any risk for increasing tumorigenesis, and whether Fhit
plays any role in the process. The purpose of this study is to investigate the effects of multi-exposure to low-dose radiation at a high
dose rate on tumorigenesis, and the role of Fhit in it. We irradiated Fhit+/+ and Fhit-/- mice with 1 Gy/1 or 0.1 Gy x 10 exposures at a
dose rate of 1 Gy/min, sacrificed the mice at 1.5 years after radiation and observed multi-organ tumorigenesis. The results showed that
although the spontaneous tumorigenesis in these mice was relatively high, 1 Gy/1-exposure dramatically increased the tumorigenesis
including lung and liver tumor. Fhit-/- mice showed more tumorigenesis than Fhit+/+ mice after 1 Gy/1- exposure. However, 0.1 Gy x 10
exposures did not increase tumorigenesis, and there was no statistical difference in tumorigenesis between Fhit+/+ mice and Fhit-/-
mice following 0.1 Gy x 10 exposures. Our results suggest that 0.1 Gy, even after multiple exposures, does not increase tumorigenesis,
and Fhit could prevent high-dose radiation-induced tumors but has no effect in a low-dose environment. (IJCEM911005).
Key words: Fhit, low dose, ionizing radiation, tumorigenesis
Full Text PDF
Address all correspondence to:
Ya Wang, PhD,
Emory University,
1365 Clifton Rd, NE
Atlanta, GA 30033, USA
Tel: (404) 778-1832, Fax: (404) 778-1750
E-mail: yawang@radonc.emory.org
