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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2(4):337-347;2009.
Original Article
Effects of erucic acid supplemented feeding on chronic doxorubucin toxicity in rats
Evin Bozcali, Öner Süzer, Hatice Nilüfer Gürsoy, Pinar Atukeren, Koray M Gümüstas
Cerrahpasa Faculty of Medicine, Departments of Cardiology, Pharmcology and Clinical Pharmacology, and Biochemistry, University of
Istanbul, Istanbul, Turkey.
Received September 12, 2009; accepted November 12, 2009; available online November 16, 2009
Abstract: One of the undesired complications of the chemotherapy with doxorubicin is cardiotoxicity. Cardiac
effect of erucic acid, which is a member of omega-9 fatty acid, is investigated on doxorubicin treatment in this
study. Forty-eight rats were divided into eight groups and each group contained six rats. First group rats were fed
with milk. In the third and fifth groups we fed rats with milk supplemented 0.5% and 5% erucic acid respectively.
The groups 2, 4, 6 were fed as the groups 1, 3, 5 respectively; we injected 2 mg/kg twice weekly intraperitoneal
doxorubicin to these groups whereas we injected isovolumous normal saline to the groups 1, 3, 5. Two other
groups (groups 7 and 8) were fed with standard pellet. Group 8 received 2 mg/kg doxorubicin twice weekly; group
7 received normal saline. After 4 weeks hearts were isolated and mounted on a Langendorff apparatus perfused
by modified Tyrode solution. Surviving rats were significantly less in erucic acid + doxorubicin groups at the end of
the treatment period (p<0.05). No significant difference was found between groups for malondialdehyde,
catalase, cytochrome c oxidase and isolated heart measurements. Concomitant application of erucic acid and
doxorubicin showed profound toxicity. (IJCEM909006).
Key words: Erucic Acid, doxorubucin, isolated perfused rat heart, cardiolipin, cytochrome c oxidase
Full Text PDF
Address all correspondence to:
Evin Bozcali, MD
Zeytinoglu Caddesi Sarikonaklar Sitesi B17/4,
Akatlar Etiler Besiktas, Istanbul, Turkey, 34335
Email: ebozcali@gmail.com
Original Article
Effects of erucic acid supplemented feeding on chronic doxorubucin toxicity in rats
Evin Bozcali, Öner Süzer, Hatice Nilüfer Gürsoy, Pinar Atukeren, Koray M Gümüstas
Cerrahpasa Faculty of Medicine, Departments of Cardiology, Pharmcology and Clinical Pharmacology, and Biochemistry, University of
Istanbul, Istanbul, Turkey.
Received September 12, 2009; accepted November 12, 2009; available online November 16, 2009
Abstract: One of the undesired complications of the chemotherapy with doxorubicin is cardiotoxicity. Cardiac
effect of erucic acid, which is a member of omega-9 fatty acid, is investigated on doxorubicin treatment in this
study. Forty-eight rats were divided into eight groups and each group contained six rats. First group rats were fed
with milk. In the third and fifth groups we fed rats with milk supplemented 0.5% and 5% erucic acid respectively.
The groups 2, 4, 6 were fed as the groups 1, 3, 5 respectively; we injected 2 mg/kg twice weekly intraperitoneal
doxorubicin to these groups whereas we injected isovolumous normal saline to the groups 1, 3, 5. Two other
groups (groups 7 and 8) were fed with standard pellet. Group 8 received 2 mg/kg doxorubicin twice weekly; group
7 received normal saline. After 4 weeks hearts were isolated and mounted on a Langendorff apparatus perfused
by modified Tyrode solution. Surviving rats were significantly less in erucic acid + doxorubicin groups at the end of
the treatment period (p<0.05). No significant difference was found between groups for malondialdehyde,
catalase, cytochrome c oxidase and isolated heart measurements. Concomitant application of erucic acid and
doxorubicin showed profound toxicity. (IJCEM909006).
Key words: Erucic Acid, doxorubucin, isolated perfused rat heart, cardiolipin, cytochrome c oxidase
Full Text PDF
Address all correspondence to:
Evin Bozcali, MD
Zeytinoglu Caddesi Sarikonaklar Sitesi B17/4,
Akatlar Etiler Besiktas, Istanbul, Turkey, 34335
Email: ebozcali@gmail.com
