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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2(3):203-211;2009.
Review Article
The Role of Hepatic Cytochrome P-450 in Sepsis
Asha Jacob, Mian Zhou, Rongqian Wu and Ping Wang
Department of Surgery, North Shore University Hospital-Long Island Jewish Medical Center and Feinstein Institute for Medical Research
350 Community Drive, Manhasset, NY 11030
Received August 13, 2009; accepted August, 2009; available online August, 2009
Abstract: Severe sepsis is a common, expensive, and fatal condition with as many deaths annually as those from acute myocardial
infarctions. The average cost per case seems to exceed $22,000. The increased morbidity and mortality attributed to sepsis could be
due to the lack of our understanding of mediators and factors responsible for early cellular alterations and thus could not be intervened
which result in progressive deterioration of cell and organ function and even death. It has been well documented that hepatocellular
dysfunction occurs early in sepsis and it contributes to multiple organ failure and ultimately death; however the exact mechanism is
poorly understood. We and others have shown that cytochrome P-450 (CYP) enzyme system, a superfamily of heme proteins
responsible for the metabolism of a variety of endogenous and exogenous substances, plays a crucial role in the prevention of
hepatocellular dysfunction in sepsis. In this review, we describe the alterations of CYP enzymes in the experimental model of sepsis
and provide the limited information available in septic and severely injured patients. We also review the potential mechanism for the
alterations of CYP enzymes in sepsis. Finally, we highlight the importance of future studies needed to understand the regulation of CYP
isoforms to develop therapy for hepatocellular dysfunction in sepsis. (IJCEM908002).
Key Words: cytochrome P-450, CYP enzymes, hepatic dysfunction, liver, sepsis
Full Text PDF
Address all correspondence to:
Ping Wang, MD
Laboratory of Surgical Research
Feinstein Institute for Medical Research
350 Community Drive
Manhasset, NY 11030
Tel: (516) 562-3411
Fax: (516) 562-1022
Email: pwang@nshs.edu
Review Article
The Role of Hepatic Cytochrome P-450 in Sepsis
Asha Jacob, Mian Zhou, Rongqian Wu and Ping Wang
Department of Surgery, North Shore University Hospital-Long Island Jewish Medical Center and Feinstein Institute for Medical Research
350 Community Drive, Manhasset, NY 11030
Received August 13, 2009; accepted August, 2009; available online August, 2009
Abstract: Severe sepsis is a common, expensive, and fatal condition with as many deaths annually as those from acute myocardial
infarctions. The average cost per case seems to exceed $22,000. The increased morbidity and mortality attributed to sepsis could be
due to the lack of our understanding of mediators and factors responsible for early cellular alterations and thus could not be intervened
which result in progressive deterioration of cell and organ function and even death. It has been well documented that hepatocellular
dysfunction occurs early in sepsis and it contributes to multiple organ failure and ultimately death; however the exact mechanism is
poorly understood. We and others have shown that cytochrome P-450 (CYP) enzyme system, a superfamily of heme proteins
responsible for the metabolism of a variety of endogenous and exogenous substances, plays a crucial role in the prevention of
hepatocellular dysfunction in sepsis. In this review, we describe the alterations of CYP enzymes in the experimental model of sepsis
and provide the limited information available in septic and severely injured patients. We also review the potential mechanism for the
alterations of CYP enzymes in sepsis. Finally, we highlight the importance of future studies needed to understand the regulation of CYP
isoforms to develop therapy for hepatocellular dysfunction in sepsis. (IJCEM908002).
Key Words: cytochrome P-450, CYP enzymes, hepatic dysfunction, liver, sepsis
Full Text PDF
Address all correspondence to:
Ping Wang, MD
Laboratory of Surgical Research
Feinstein Institute for Medical Research
350 Community Drive
Manhasset, NY 11030
Tel: (516) 562-3411
Fax: (516) 562-1022
Email: pwang@nshs.edu
