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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2(3):212-220;2009.
Original Article
Induction of antigen-specific immune tolerance by TGF-β-induced CD4+Foxp3+
regulatory T cells
Huimin Fan, Julie Wang, Xiaohui Zhou, Zhongmin Liu, Song Guo Zheng
Department of Surgery, East Hospital at Tongji University; Department of Medicine, University of Southern California
Received July 29, 2009; accepted August 10, 2009; available online August 18, 2009
Abstract: Like natural CD4+CD25+ Treg cells, TGF-β-induced Treg cells also prevent allograft rejection in MHC-mismatched organ
transplantation models. In analyzing this effect with greater detail, we determined that injection of TGF-β-induced, alloactivated
CD4+CD25+ cells induces antigen-specific immune tolerance in vivo. Increased CD4+CD25+ cells in recipients contribute to this
immune tolerance. In addition, adoptive transfer of TGF-β-induced CD4+CD25+ cells did not result in significant toxic and side effects in
recipients. These results indicate that TGF-β-induced, alloactivated CD4+CD25+ cells may provide a safe and effective approach to
protect MHC-mismatched organ grafts from rejection in a clinical setting. (IJCEM907005).
Key Words: TGF-β, Foxp3, regulatory T cells, Immunoregulation, transplant tolerance
Full Text PDF
Address all correspondence to:
Song Guo Zheng, MD, PhD
2011 Zonal Ave. HMR710A
Los Angeles, CA 90033
Department of Medicine
University of Southern California
Tel: 323 442 2128; Fax: 323 442 2874;
Email: szheng@usc.edu
or
Zhongmin Liu, MD, PhD
150 Jimo Road, Shanghai, 200031
Department of Surgery
East Hospital at Tongji University
Tel: 086-21-58409274; Fax: 086-21-58761951
Email: Zhongmin_liu@sina.com
Original Article
Induction of antigen-specific immune tolerance by TGF-β-induced CD4+Foxp3+
regulatory T cells
Huimin Fan, Julie Wang, Xiaohui Zhou, Zhongmin Liu, Song Guo Zheng
Department of Surgery, East Hospital at Tongji University; Department of Medicine, University of Southern California
Received July 29, 2009; accepted August 10, 2009; available online August 18, 2009
Abstract: Like natural CD4+CD25+ Treg cells, TGF-β-induced Treg cells also prevent allograft rejection in MHC-mismatched organ
transplantation models. In analyzing this effect with greater detail, we determined that injection of TGF-β-induced, alloactivated
CD4+CD25+ cells induces antigen-specific immune tolerance in vivo. Increased CD4+CD25+ cells in recipients contribute to this
immune tolerance. In addition, adoptive transfer of TGF-β-induced CD4+CD25+ cells did not result in significant toxic and side effects in
recipients. These results indicate that TGF-β-induced, alloactivated CD4+CD25+ cells may provide a safe and effective approach to
protect MHC-mismatched organ grafts from rejection in a clinical setting. (IJCEM907005).
Key Words: TGF-β, Foxp3, regulatory T cells, Immunoregulation, transplant tolerance
Full Text PDF
Address all correspondence to:
Song Guo Zheng, MD, PhD
2011 Zonal Ave. HMR710A
Los Angeles, CA 90033
Department of Medicine
University of Southern California
Tel: 323 442 2128; Fax: 323 442 2874;
Email: szheng@usc.edu
or
Zhongmin Liu, MD, PhD
150 Jimo Road, Shanghai, 200031
Department of Surgery
East Hospital at Tongji University
Tel: 086-21-58409274; Fax: 086-21-58761951
Email: Zhongmin_liu@sina.com
