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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2(2),159-175;2009
Original Article
Vitamin D receptor genetic polymorphisms and prostate cancer risk: a
Meta-analysis of 36 published studies
Ming Yin, Sheng Wei, Qingyi Wei
Departments of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX77030, USA.
Received May 21, 2009; accepted June , 2009; available online June , 2009
Abstract: To update data on the role of vitamin D receptor single nucleotide polymorphisms in susceptibility to prostate cancer, we
performed a meta-analysis on the association of TaqI, ApaI, BsmI, FokI and CDX2 SNPs with prostate cancer risks, using 37 eligible
publications. Our study suggested that the TaqI t allele and BsmI B allele were associated with reduced prostate cancer risk among all
study populations. Stratified analysis by ethnicity revealed that the ApaI a allele was associated with reduced prostate cancer risk
among Asian populations, whereas the FokI f allele showed a trend of increased prostate cancer risk among Caucasian populations in
a dominant mode, independent of tumor stage (local or advanced). These results suggest that VDR polymorphisms may be potential
biomarkers for prostate cancer susceptibility. (IJCEM905005).
Key Words: Prostate cancer, genetic polymorphism, meta-analysis, molecular epidemiology
Full Text PDF
Address all correspondence to:
Qingyi Wei, MD, PhD
Department of Epidemiology
The University of Texas, M. D. Anderson Cancer Center
1515 Holcombe Blvd, Unit 1365
Houston, TX77030, USA
Tel: 713-792-3020; Fax: 713-563-0999
Email: qwei@mdanderson.org
Original Article
Vitamin D receptor genetic polymorphisms and prostate cancer risk: a
Meta-analysis of 36 published studies
Ming Yin, Sheng Wei, Qingyi Wei
Departments of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX77030, USA.
Received May 21, 2009; accepted June , 2009; available online June , 2009
Abstract: To update data on the role of vitamin D receptor single nucleotide polymorphisms in susceptibility to prostate cancer, we
performed a meta-analysis on the association of TaqI, ApaI, BsmI, FokI and CDX2 SNPs with prostate cancer risks, using 37 eligible
publications. Our study suggested that the TaqI t allele and BsmI B allele were associated with reduced prostate cancer risk among all
study populations. Stratified analysis by ethnicity revealed that the ApaI a allele was associated with reduced prostate cancer risk
among Asian populations, whereas the FokI f allele showed a trend of increased prostate cancer risk among Caucasian populations in
a dominant mode, independent of tumor stage (local or advanced). These results suggest that VDR polymorphisms may be potential
biomarkers for prostate cancer susceptibility. (IJCEM905005).
Key Words: Prostate cancer, genetic polymorphism, meta-analysis, molecular epidemiology
Full Text PDF
Address all correspondence to:
Qingyi Wei, MD, PhD
Department of Epidemiology
The University of Texas, M. D. Anderson Cancer Center
1515 Holcombe Blvd, Unit 1365
Houston, TX77030, USA
Tel: 713-792-3020; Fax: 713-563-0999
Email: qwei@mdanderson.org
