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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(4),305-309;2008
Original Article
Associate with Increased Marker of Oxidative Stress
Anshu Agrawal, Elaine V. Lourenço, Sudhir Gupta and Antonio La Cava
Division of Basic and Clinical Immunology, University of California Irvine, Department of Medicine, University of California Los Angeles,
CA, USA
Received July 17, 2008; accepted August 5, 2008; available online August 12, 2008
Abstract: Aging associates with an increased pro-inflammatory activity that is commonly associated with oxidative tissue damage.
One pro-inflammatory molecule that facilitates oxidative stress is leptin, a hormone that regulates metabolism, endocrine and immune
functions. To address whether leptin levels correlated with oxidative stress in aging, we performed cross-sectional measurements of
circulating plasma leptin in groups of healthy individuals that were divided by age and gender. It was found that leptin levels were
comparable between young (N=54) and elderly humans (N=56) in each gender, and women had higher levels than men, irrespectively
of age. Interestingly, oxidative stress measured as total glutathione levels correlated positively with elevated leptin levels in elderly
women but not in men or in the groups of younger individuals. The data suggest that a gender bias for leptin that is maintained with
age can associate with increased propensity to oxidative stress in the elderly. (IJCEM807004).
Key Words: Leptin, aging, gender, oxidative stress
Full Text PDF
Address all correspondence to: Antonio La Cava, MD, PhD, Department of Medicine, University of California Los Angeles, Los
Angeles, California 90095-1670; Tel. 310 267-4975; Fax: 310 206-8606; E-mail: alacava@mednet.ucla.edu
Original Article
Associate with Increased Marker of Oxidative Stress
Anshu Agrawal, Elaine V. Lourenço, Sudhir Gupta and Antonio La Cava
Division of Basic and Clinical Immunology, University of California Irvine, Department of Medicine, University of California Los Angeles,
CA, USA
Received July 17, 2008; accepted August 5, 2008; available online August 12, 2008
Abstract: Aging associates with an increased pro-inflammatory activity that is commonly associated with oxidative tissue damage.
One pro-inflammatory molecule that facilitates oxidative stress is leptin, a hormone that regulates metabolism, endocrine and immune
functions. To address whether leptin levels correlated with oxidative stress in aging, we performed cross-sectional measurements of
circulating plasma leptin in groups of healthy individuals that were divided by age and gender. It was found that leptin levels were
comparable between young (N=54) and elderly humans (N=56) in each gender, and women had higher levels than men, irrespectively
of age. Interestingly, oxidative stress measured as total glutathione levels correlated positively with elevated leptin levels in elderly
women but not in men or in the groups of younger individuals. The data suggest that a gender bias for leptin that is maintained with
age can associate with increased propensity to oxidative stress in the elderly. (IJCEM807004).
Key Words: Leptin, aging, gender, oxidative stress
Full Text PDF
Address all correspondence to: Antonio La Cava, MD, PhD, Department of Medicine, University of California Los Angeles, Los
Angeles, California 90095-1670; Tel. 310 267-4975; Fax: 310 206-8606; E-mail: alacava@mednet.ucla.edu
