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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(4),319-326;2008
Original Article
Fasting Plasma Glucose Levels Are Related to Bone Mineral Density in
Postmenopausal Women with Primary Hyperparathyroidism
Itoko Hisa, Hiroshi Kaji, Yoshifumi Inoue, Toshitsugu Sugimoto, and Kazuo Chihara
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine,
7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho,
Izumo, Shimane, 693-8501, Japan
Received July 2, 2008; accepted September 19, 2008; available online September 22, 2008
Abstract: How glucose levels affect bone in patients with primary hyperparathyroidism is unknown, although the prevalence of
impaired glucose metabolism is higher in patients with primary hyperparathyroidism. The present study was performed to examine the
relationships between fasting plasma glucose (FPG) and various indices in 93 postmenopausal women with primary
hyperparathyroidism. Bone mineral density (BMD) and body composition were measured by dual-energy Xray absorptiometry. Body
weight, body mass index (BMI), fat mass and % fat were positively related to FPG. Serum levels of calcium and parathyroid hormone
(PTH) as well as bone metabolic indices were not related to FPG and immunoreactive insulin levels. As for BMD, FPG was positively
related to the Z scores of BMD at the lumbar spine and femoral neck, although it was not significantly related to the Z-score of BMD at
the radius. On the other hand, immunoreactive insulin levels were not significantly related to BMD parameters at any sites. In multiple
regression analysis, FPG was significantly related to BMD (Z score) at the lumbar spine and femoral neck, when body weight, BMI,
immunoreactive insulin, PTH, and bone resorption indices were considered; however, these relationships at the lumbar spine were not
significant when fat mass was considered. In conclusion, the present study indicated that FPG levels were positively related to BMD at
the lumbar spine and femoral neck in postmenopausal women with primary hyperparathyroidism. (IJCEM807001).
Key Words: Primary hyperparathyroidism, glucose, bone mineral density, body composition
Full Text PDF
Address all correspondence to: Hiroshi Kaji, MD, Division of Diabetes, Metabolism and Endocrinology, Department of Internal
Medicine, Kobe University Graduate School of Medicine. 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Phone:
81-78-382-5861, Fax: 81-78-382-2080 E-mail: hiroshik@med.kobe-u.ac.jp
Original Article
Fasting Plasma Glucose Levels Are Related to Bone Mineral Density in
Postmenopausal Women with Primary Hyperparathyroidism
Itoko Hisa, Hiroshi Kaji, Yoshifumi Inoue, Toshitsugu Sugimoto, and Kazuo Chihara
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine,
7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho,
Izumo, Shimane, 693-8501, Japan
Received July 2, 2008; accepted September 19, 2008; available online September 22, 2008
Abstract: How glucose levels affect bone in patients with primary hyperparathyroidism is unknown, although the prevalence of
impaired glucose metabolism is higher in patients with primary hyperparathyroidism. The present study was performed to examine the
relationships between fasting plasma glucose (FPG) and various indices in 93 postmenopausal women with primary
hyperparathyroidism. Bone mineral density (BMD) and body composition were measured by dual-energy Xray absorptiometry. Body
weight, body mass index (BMI), fat mass and % fat were positively related to FPG. Serum levels of calcium and parathyroid hormone
(PTH) as well as bone metabolic indices were not related to FPG and immunoreactive insulin levels. As for BMD, FPG was positively
related to the Z scores of BMD at the lumbar spine and femoral neck, although it was not significantly related to the Z-score of BMD at
the radius. On the other hand, immunoreactive insulin levels were not significantly related to BMD parameters at any sites. In multiple
regression analysis, FPG was significantly related to BMD (Z score) at the lumbar spine and femoral neck, when body weight, BMI,
immunoreactive insulin, PTH, and bone resorption indices were considered; however, these relationships at the lumbar spine were not
significant when fat mass was considered. In conclusion, the present study indicated that FPG levels were positively related to BMD at
the lumbar spine and femoral neck in postmenopausal women with primary hyperparathyroidism. (IJCEM807001).
Key Words: Primary hyperparathyroidism, glucose, bone mineral density, body composition
Full Text PDF
Address all correspondence to: Hiroshi Kaji, MD, Division of Diabetes, Metabolism and Endocrinology, Department of Internal
Medicine, Kobe University Graduate School of Medicine. 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Phone:
81-78-382-5861, Fax: 81-78-382-2080 E-mail: hiroshik@med.kobe-u.ac.jp
