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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(3):192-202;2008
Review Article
The Critical Role of TGF-β1 in the Development of Induced Foxp3+ Regulatory T
Cells
Song Guo Zheng
Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los
Angeles, CA. 90033, USA
Received May 16, 2008; accepted June, 2008; available online June, 2008
Abstract: Foxp3+ T regulatory cell (Treg) subsets play a crucial role in the maintenance of immune homeostasis against self-antigen.
The lack or dysfunction of these cells is responsible for the pathogenesis and development of many autoimmune diseases. Therefore,
manipulation of these cells may provide a novel therapeutic approach to treat autoimmune diseases and prevent allograft rejection
during organ transplantation. In the article, we will provide current opinions concerning the classification, developmental and functional
characterizations of Treg subsets. A particular emphasis will be focused on transforming cell growth factor beta (TGF-β) and its role in
the differentiation and development of induced regulatory T cells (iTregs) in the periphery. Moreover, the similarity and disparity of iTregs
and naturally occurring, thymus-derived CD4+CD25+Foxp3+ regulatory T cells (nTregs) will also be discussed. While proinflammatory
cytokine IL-6 can convert nTregs to IL-17-producing cells, peripheral Tregs induced by TGF-β are resistant to this cytokine. This
difference may affect the role of each in the adaptive immune response. (IJCEM805006).
Key Words: Immunoregulation; regulatory T cells; TGF-β; Foxp3; Th17 cells
Full Text PDF
Address all correspondence to: Song Guo Zheng, MD, USC Keck School of Medicine, 2011 Zonal Ave., HMR 710A, Los Angeles, CA
90033, Phone: (323) 442-2128, Fax: (323) 442-2874, E-mail: szheng@usc.edu
Review Article
The Critical Role of TGF-β1 in the Development of Induced Foxp3+ Regulatory T
Cells
Song Guo Zheng
Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los
Angeles, CA. 90033, USA
Received May 16, 2008; accepted June, 2008; available online June, 2008
Abstract: Foxp3+ T regulatory cell (Treg) subsets play a crucial role in the maintenance of immune homeostasis against self-antigen.
The lack or dysfunction of these cells is responsible for the pathogenesis and development of many autoimmune diseases. Therefore,
manipulation of these cells may provide a novel therapeutic approach to treat autoimmune diseases and prevent allograft rejection
during organ transplantation. In the article, we will provide current opinions concerning the classification, developmental and functional
characterizations of Treg subsets. A particular emphasis will be focused on transforming cell growth factor beta (TGF-β) and its role in
the differentiation and development of induced regulatory T cells (iTregs) in the periphery. Moreover, the similarity and disparity of iTregs
and naturally occurring, thymus-derived CD4+CD25+Foxp3+ regulatory T cells (nTregs) will also be discussed. While proinflammatory
cytokine IL-6 can convert nTregs to IL-17-producing cells, peripheral Tregs induced by TGF-β are resistant to this cytokine. This
difference may affect the role of each in the adaptive immune response. (IJCEM805006).
Key Words: Immunoregulation; regulatory T cells; TGF-β; Foxp3; Th17 cells
Full Text PDF
Address all correspondence to: Song Guo Zheng, MD, USC Keck School of Medicine, 2011 Zonal Ave., HMR 710A, Los Angeles, CA
90033, Phone: (323) 442-2128, Fax: (323) 442-2874, E-mail: szheng@usc.edu
