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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(3),267-273;2008
Original Article
Diurnal Variations in Human Pulmonary Function
Boris I. Medarov, Valentin A. Pavlov and Leonard Rossoff
Department of Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, Long Island Campus of Albert Einstein
College of Medicine, New Hyde Park, NY; Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset,
NY 11030, USA
Received May 7, 2008; accepted July 9, 2008; available online July 12, 2008
Abstract: Pulmonary function has circadian modulations. Variations in human pulmonary function during the daytime hours (diurnal
variations) remain to be well characterized. Discerning these variations will contribute to better understanding the relationship between
biorhythms and lung physiology and to improving clinical management of pulmonary diseases. The aim of this study was to determine
the magnitude of pulmonary function variability during the usual daytime hours in a population of patients referred for pulmonary
function testing. Diurnal fluctuations of human pulmonary function were examined by studying retrospectively a study population of
4,756 individuals with performed pulmonary function tests. We found the lowest and highest spirometric values in the 12:00-12:59 pm
and 3:00-4:59 pm time intervals respectively. The difference in the forced expiratory volume in 1 second (FEV1) between the noon
(12:00-12:59 pm) and afternoon (4:00-4:59 pm) intervals was 17.6% (P<0.01). Furthermore, the highest values of diffusing capacity of
the lung for carbon monoxide [DLCO] and alveolar volume [Va] were identified in the 8:00-8:59 am time interval. These findings,
identifying a model of diurnal variations of pulmonary function in individuals referred for pulmonary function testing, are of interest for
better understanding lung physiology and human circadian rhythms and may have clinical value in managing lung disorders.
(IJCEM805004).
Key Words: Pulmonary function; diurnal variations; pulmonary function tests; diffusing capacity; pulmonary diseases
Full Text PDF
Address all correspondence to: Boris Medarov, MD, Charlotte Hungerford Hospital, 540 Litchfield Street, Torrington, CT 06790, Tel.
(860) 496-6666, Fax (516) 562-2356, E-mail: medaroff@yahoo.com
Original Article
Diurnal Variations in Human Pulmonary Function
Boris I. Medarov, Valentin A. Pavlov and Leonard Rossoff
Department of Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, Long Island Campus of Albert Einstein
College of Medicine, New Hyde Park, NY; Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset,
NY 11030, USA
Received May 7, 2008; accepted July 9, 2008; available online July 12, 2008
Abstract: Pulmonary function has circadian modulations. Variations in human pulmonary function during the daytime hours (diurnal
variations) remain to be well characterized. Discerning these variations will contribute to better understanding the relationship between
biorhythms and lung physiology and to improving clinical management of pulmonary diseases. The aim of this study was to determine
the magnitude of pulmonary function variability during the usual daytime hours in a population of patients referred for pulmonary
function testing. Diurnal fluctuations of human pulmonary function were examined by studying retrospectively a study population of
4,756 individuals with performed pulmonary function tests. We found the lowest and highest spirometric values in the 12:00-12:59 pm
and 3:00-4:59 pm time intervals respectively. The difference in the forced expiratory volume in 1 second (FEV1) between the noon
(12:00-12:59 pm) and afternoon (4:00-4:59 pm) intervals was 17.6% (P<0.01). Furthermore, the highest values of diffusing capacity of
the lung for carbon monoxide [DLCO] and alveolar volume [Va] were identified in the 8:00-8:59 am time interval. These findings,
identifying a model of diurnal variations of pulmonary function in individuals referred for pulmonary function testing, are of interest for
better understanding lung physiology and human circadian rhythms and may have clinical value in managing lung disorders.
(IJCEM805004).
Key Words: Pulmonary function; diurnal variations; pulmonary function tests; diffusing capacity; pulmonary diseases
Full Text PDF
Address all correspondence to: Boris Medarov, MD, Charlotte Hungerford Hospital, 540 Litchfield Street, Torrington, CT 06790, Tel.
(860) 496-6666, Fax (516) 562-2356, E-mail: medaroff@yahoo.com
