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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(10):991-995
Original Article
Overweight and obesity adversely affect outcomes of assisted reproductive
technologies in polycystic ovary syndrome patients
Zhiqin Bu, Wei Dai, Yihong Guo, Yingchun Su, Jun Zhai, Yingpu Sun
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, People’s Republic of China. Equal contributors.
Received September 13, 2013; Accepted October 18, 2013; Epub October 25, 2013; Published October 30, 2013
Abstract: Overweight and obesity may have negative impact on IVF/ICSI treatment outcomes. However, it is not clear whether
overweight and obesity have impact on IVF/ICSI outcomes in PCOS patients. The aim of this study was to examine the effect of
overweight and obesity on IVF/ICSI treatment outcomes in PCOS patients treated with GnRH agonist long protocol. This retrospective
study was conducted in a reproductive medicine center from January 2009 to June 2013. IVF/ICSI characteristics and outcomes were
analyzed in 688 PCOS patients according to their BMI. A total of 409 normal weight patients (group A, 18.5 kg/m2 ≤ BMI <24 kg/m2) and
279 overweight and obese patients (group B, BMI ≥24 kg/m2) were included into this study. Patient age, basal FSH, basal LH and peak
E2 concentration were comparable in the two groups. Compared with patients in group A, patients in group B had similar number of
retrieved oocytes, 2PN, and high quality embryos. However, overweight and obese women needed more ampoules of gonadotrophin
and longer days of stimulation. In addition, the implantation rate (38.3% vs. 35.6%; P=0.000) was also higher in normal weight patients.
Overweight and obese women seemed to have lower clinical pregnancy rate (56.9% vs. 53.4%; P>0.05), but the difference was not
statistically significant. In conclusion, overweight and obesity is associated with unfavorable IVF/ICSI outcomes in PCOS patients
treated with GnRH agonist long protocol. (IJCEM1309012).
Keywords: Overweight, obese, PCOS, in vitro fertilization
Address correspondence to: Dr. Yingpu Sun, Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, 1#,
Jianshe East Road, Zhengzhou, Henan, People’s Republic of China. Tel: (86) 13503841888; Fax: (86) 37167963114; E-mail:
syp2008@vip.sina.com
Original Article
Overweight and obesity adversely affect outcomes of assisted reproductive
technologies in polycystic ovary syndrome patients
Zhiqin Bu, Wei Dai, Yihong Guo, Yingchun Su, Jun Zhai, Yingpu Sun
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, People’s Republic of China. Equal contributors.
Received September 13, 2013; Accepted October 18, 2013; Epub October 25, 2013; Published October 30, 2013
Abstract: Overweight and obesity may have negative impact on IVF/ICSI treatment outcomes. However, it is not clear whether
overweight and obesity have impact on IVF/ICSI outcomes in PCOS patients. The aim of this study was to examine the effect of
overweight and obesity on IVF/ICSI treatment outcomes in PCOS patients treated with GnRH agonist long protocol. This retrospective
study was conducted in a reproductive medicine center from January 2009 to June 2013. IVF/ICSI characteristics and outcomes were
analyzed in 688 PCOS patients according to their BMI. A total of 409 normal weight patients (group A, 18.5 kg/m2 ≤ BMI <24 kg/m2) and
279 overweight and obese patients (group B, BMI ≥24 kg/m2) were included into this study. Patient age, basal FSH, basal LH and peak
E2 concentration were comparable in the two groups. Compared with patients in group A, patients in group B had similar number of
retrieved oocytes, 2PN, and high quality embryos. However, overweight and obese women needed more ampoules of gonadotrophin
and longer days of stimulation. In addition, the implantation rate (38.3% vs. 35.6%; P=0.000) was also higher in normal weight patients.
Overweight and obese women seemed to have lower clinical pregnancy rate (56.9% vs. 53.4%; P>0.05), but the difference was not
statistically significant. In conclusion, overweight and obesity is associated with unfavorable IVF/ICSI outcomes in PCOS patients
treated with GnRH agonist long protocol. (IJCEM1309012).
Keywords: Overweight, obese, PCOS, in vitro fertilization
Address correspondence to: Dr. Yingpu Sun, Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, 1#,
Jianshe East Road, Zhengzhou, Henan, People’s Republic of China. Tel: (86) 13503841888; Fax: (86) 37167963114; E-mail:
syp2008@vip.sina.com
