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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(8):706-711
Original Article
Circulating levels of erythropoietin and its relation to arterial stiffness in patients
with hypertension
Omer Gedikli, Abdulkadir Kiris, Caner Karahan
Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey; Department of Biochemistry, Ozel
Yildizliguven Hospital, Trabzon, Turkey
Received July 23, 2013; Accepted August 15, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Background: Emerging experimental and clinical data indicates that erythropoietin (EPO) have significant roles in the
cardiovascular system. But the relationship between endogenous EPO levels and arterial stiffness remains unknown. We investigated
the EPO levels in relation to arterial stiffness parameters in patients with never treated newly diagnosed hypertension (HT). Methods:
We studied 42 (47.8 ± 10 years) never treated HT patients and age and gender-matched 40 (47 ± 8.6 years) normotensive individuals.
Serum EPO levels were determined in all subjects using the chemiluminescence immunoassay kit. We evaluated heart rate-corrected
augmentation index (AIx@75), a marker of wave reflections and aortic pulse wave velocity (PWV) as indices of elastic-type aortic
stiffness using applanation tonometry (Sphygmocor). Results: The levels of EPO were not significantly different in hypertensive patients
and the controls (10.6 ± 5 vs. 11.6 ± 9, mIU/mL, p = 0.5). Aortic PWV (10.3 ± 2.3 vs. 8.7 ± 1.6 m/s, p = 0.0001) and AIx@75 (22.7 ± 10 vs.
15 ± 11, %, p = 0.002) were significantly higher in hypertensive patients than the controls. EPO levels were not correlated with brachial
and central pressures. Also EPO level was not significantly correlated with AIx@75 (r = -0.15, p = 0.17) and aortic PWV (r = -0.16, p =
0.13). Conclusion: Results from this study indicate that endogenous EPO levels may not be a factor in development of increased
arterial stiffness. (IJCEM1307018).
Keywords: Erythropoietin, arterial stiffness
Address correspondence to: Dr. Omer Gedikli, Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, 61080
Trabzon, Turkey. Tel: + 90 462 377 55 57; Fax: +90 462 377 53 96; E-mail: dromergedikli@gmail.com
Original Article
Circulating levels of erythropoietin and its relation to arterial stiffness in patients
with hypertension
Omer Gedikli, Abdulkadir Kiris, Caner Karahan
Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey; Department of Biochemistry, Ozel
Yildizliguven Hospital, Trabzon, Turkey
Received July 23, 2013; Accepted August 15, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Background: Emerging experimental and clinical data indicates that erythropoietin (EPO) have significant roles in the
cardiovascular system. But the relationship between endogenous EPO levels and arterial stiffness remains unknown. We investigated
the EPO levels in relation to arterial stiffness parameters in patients with never treated newly diagnosed hypertension (HT). Methods:
We studied 42 (47.8 ± 10 years) never treated HT patients and age and gender-matched 40 (47 ± 8.6 years) normotensive individuals.
Serum EPO levels were determined in all subjects using the chemiluminescence immunoassay kit. We evaluated heart rate-corrected
augmentation index (AIx@75), a marker of wave reflections and aortic pulse wave velocity (PWV) as indices of elastic-type aortic
stiffness using applanation tonometry (Sphygmocor). Results: The levels of EPO were not significantly different in hypertensive patients
and the controls (10.6 ± 5 vs. 11.6 ± 9, mIU/mL, p = 0.5). Aortic PWV (10.3 ± 2.3 vs. 8.7 ± 1.6 m/s, p = 0.0001) and AIx@75 (22.7 ± 10 vs.
15 ± 11, %, p = 0.002) were significantly higher in hypertensive patients than the controls. EPO levels were not correlated with brachial
and central pressures. Also EPO level was not significantly correlated with AIx@75 (r = -0.15, p = 0.17) and aortic PWV (r = -0.16, p =
0.13). Conclusion: Results from this study indicate that endogenous EPO levels may not be a factor in development of increased
arterial stiffness. (IJCEM1307018).
Keywords: Erythropoietin, arterial stiffness
Address correspondence to: Dr. Omer Gedikli, Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, 61080
Trabzon, Turkey. Tel: + 90 462 377 55 57; Fax: +90 462 377 53 96; E-mail: dromergedikli@gmail.com
