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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(8):621-631
Original Article
Signal transducer and activator of transcription 6 polymorphism and asthma risk: a
meta-analysis
Bin Li, Wei Nie, Qiong Li, Hongchao Liu, Shiyuan Liu
Department of Radiology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003,
China; Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003,
China. Equal contributors.
Received July 17, 2013; Accepted August 13, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Background: The polymorphism in the signal transducer and activators of transduction 6 (STAT6) gene has been implicated
in susceptibility to asthma and aetiology of asthma, but a number of studies have reported inconclusive and ambiguous results of the
association between polymorphism in STAT6 gene and asthma risk in different populations. The aim of this study is to further
investigate the association between the STAT6 gene polymorphism and asthma susceptibility. Methods: Pubmed, EMBASE, China
National Knowledge Infrastructure (CNKI) Weipu Database and Wanfang Database were searched to find relevant studies. Odds ratios
(ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results: Included in this meta analysis
were 14 studies involving 2875 cases and 3227 controls for STAT6 2964G/A polymorphism and six studies involving 1431 cases and
2027 controls for 2892C/T polymorphism. Overall, there was no significant association between 2964G/A polymorphism of STAT6 and
asthma susceptibility for GA+AA vs. GG (OR = 0.96, 95% CI 0.85-1.07, P = 0.39). Except TT vs. CT+CC and TT vs. CC, no significant
association was observed between 2892C/T polymorphism and asthma risk under other different contrast models. However, the result
was instable. Conclusions: This meta-analysis suggests that the 2964G/A polymorphism of STAT6 gene is not a risk factor of asthma.
For 2892C/T, it contributes to the aetiology of or susceptibility to asthma. More studies are needed to validate this result.
(IJCEM1307012).
Keywords: Asthma, signal transducer and activator of transcription 6, meta-analysis, polymorphism
Address correspondence to: Dr. Shiyuan Liu, Department of Radiology, Changzheng Hospital, Second Military Medical University, 415
Fengyang Road, Shanghai 200003, China. Tel: 86-021-81886011; Fax: 86-021-63587669; E-mail: lsy20112077@163.com
Original Article
Signal transducer and activator of transcription 6 polymorphism and asthma risk: a
meta-analysis
Bin Li, Wei Nie, Qiong Li, Hongchao Liu, Shiyuan Liu
Department of Radiology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003,
China; Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003,
China. Equal contributors.
Received July 17, 2013; Accepted August 13, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Background: The polymorphism in the signal transducer and activators of transduction 6 (STAT6) gene has been implicated
in susceptibility to asthma and aetiology of asthma, but a number of studies have reported inconclusive and ambiguous results of the
association between polymorphism in STAT6 gene and asthma risk in different populations. The aim of this study is to further
investigate the association between the STAT6 gene polymorphism and asthma susceptibility. Methods: Pubmed, EMBASE, China
National Knowledge Infrastructure (CNKI) Weipu Database and Wanfang Database were searched to find relevant studies. Odds ratios
(ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results: Included in this meta analysis
were 14 studies involving 2875 cases and 3227 controls for STAT6 2964G/A polymorphism and six studies involving 1431 cases and
2027 controls for 2892C/T polymorphism. Overall, there was no significant association between 2964G/A polymorphism of STAT6 and
asthma susceptibility for GA+AA vs. GG (OR = 0.96, 95% CI 0.85-1.07, P = 0.39). Except TT vs. CT+CC and TT vs. CC, no significant
association was observed between 2892C/T polymorphism and asthma risk under other different contrast models. However, the result
was instable. Conclusions: This meta-analysis suggests that the 2964G/A polymorphism of STAT6 gene is not a risk factor of asthma.
For 2892C/T, it contributes to the aetiology of or susceptibility to asthma. More studies are needed to validate this result.
(IJCEM1307012).
Keywords: Asthma, signal transducer and activator of transcription 6, meta-analysis, polymorphism
Address correspondence to: Dr. Shiyuan Liu, Department of Radiology, Changzheng Hospital, Second Military Medical University, 415
Fengyang Road, Shanghai 200003, China. Tel: 86-021-81886011; Fax: 86-021-63587669; E-mail: lsy20112077@163.com
