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Int J Clin Exp Med 2013;6(8):649-654
Original Article
Clinical study on the treatment of chronic wound with negatively-charged aerosol
Xiaoxia Xie, Lei Chen, Zhao-Qiang Zhang, Yan Shi, Julin Xie
Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; Department of Oral and
Maxillofacial Surgery, Hospital of Stomatology, Guangzhou Medical University, 39 Huangsha Road, Liwan District, Guangzhou City,
Guangdong Province, China. Equal contributors.
Received June 16, 2013; Accepted July 1, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Background: Aerosols are defined as the mixture of liquid or solid particles/droplets that are stably suspending in air. When
carrying a certain amount of negative charge, they will be defined as negatively-charged aerosol. This report investigates the effect of
negatively-charged aerosol on the healing of chronic wound. Methods: 140 patients with chronic wound were assigned randomly into
two groups. Normal, routine treatment was applied on chronic wounds of 73 patients depending on wounds situation (control group).
While another 67 similar patients received negatively-charged aerosol therapy (2 hours per time, twice a day) and were used as
experimental group. Wound healing assessment including the patients’ complication, detection of bacteria in wound secretions, and
evaluation of wound healing. Results: The results of our study showed that after the application of negatively-charged aerosols, and
condition and infection rate of wounds from experiment group were better and lower than that of control group. In comparison with
control group, the relative size of wounds from experiment group was significantly smaller (P<0.05) at post-treatment day 0, 7, 14, 21
and 28. Also, the time required for wound healing in the experimental group was significantly shorter (P<0.05) than that in the control
group. Conclusion: Negatively-charged aerosol therapy can accelerate wound healing speed and improve the healing of chronic
wounds. Thus, we wound recommend the consideration of Negatively-charged aerosol therapies in addition to normal wound
treatment in cases of chronic wound. (IJCEM1306013).
Keywords: Negatively-charged aerosol, healing, chronic wound
Address correspondence to: Dr. Julin Xie, Department of Burns Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou,
Guangdong 510080, China. E-mail: gz3x111@163.com
Original Article
Clinical study on the treatment of chronic wound with negatively-charged aerosol
Xiaoxia Xie, Lei Chen, Zhao-Qiang Zhang, Yan Shi, Julin Xie
Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; Department of Oral and
Maxillofacial Surgery, Hospital of Stomatology, Guangzhou Medical University, 39 Huangsha Road, Liwan District, Guangzhou City,
Guangdong Province, China. Equal contributors.
Received June 16, 2013; Accepted July 1, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Background: Aerosols are defined as the mixture of liquid or solid particles/droplets that are stably suspending in air. When
carrying a certain amount of negative charge, they will be defined as negatively-charged aerosol. This report investigates the effect of
negatively-charged aerosol on the healing of chronic wound. Methods: 140 patients with chronic wound were assigned randomly into
two groups. Normal, routine treatment was applied on chronic wounds of 73 patients depending on wounds situation (control group).
While another 67 similar patients received negatively-charged aerosol therapy (2 hours per time, twice a day) and were used as
experimental group. Wound healing assessment including the patients’ complication, detection of bacteria in wound secretions, and
evaluation of wound healing. Results: The results of our study showed that after the application of negatively-charged aerosols, and
condition and infection rate of wounds from experiment group were better and lower than that of control group. In comparison with
control group, the relative size of wounds from experiment group was significantly smaller (P<0.05) at post-treatment day 0, 7, 14, 21
and 28. Also, the time required for wound healing in the experimental group was significantly shorter (P<0.05) than that in the control
group. Conclusion: Negatively-charged aerosol therapy can accelerate wound healing speed and improve the healing of chronic
wounds. Thus, we wound recommend the consideration of Negatively-charged aerosol therapies in addition to normal wound
treatment in cases of chronic wound. (IJCEM1306013).
Keywords: Negatively-charged aerosol, healing, chronic wound
Address correspondence to: Dr. Julin Xie, Department of Burns Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou,
Guangdong 510080, China. E-mail: gz3x111@163.com
