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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(5):342-345
Original Article
Preliminary study on plasma RPN concentration of patients with infantile
hemangioma treated with propranolol
Ling Zhang, Hua-Ming Mai, Jing Zheng, Jia-Wei Zheng, Zheng-Gang Chen, Yan-An Wang, Zhong-Ping Qin, Ke-Lei Li, Wei-En Yuan
Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School
of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, PR China; Laboratory of Molecular Neuropharmacology,
School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai, 200237, PR China; Special
Department of Vascular Anomalies, Linyi Tumor Hospital, Linyi 276000, Shandong Province, PR China; School of Pharmacy, Shanghai
Jiao Tong University, Shanghai 200011, PR China; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi
Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, PR China. Co-first author.
Received April 19, 2013; Accepted May 4, 2013; Epub May 22, 2013; Published June 1, 2013
Abstract: Propranolol (PRN) has recently been recommended as the first-line medicine for complicated infantile hemangiomas (IHs),
because of the significant effect. However, no pharmacokinetic parameters have ever been reported for infants who receive PRN
treatment for IH. In this study, we show that plasma PRN concentration is affected by the frequency of administration of PRN. A single
daily administration of PRN (1 mg/kg/d) resulted in an early elevation of plasma PRN compared to a twice a day administration of the
same dose. In contrast, the twice a day application resulted in a more prolonged expression at a later time-point. Our findings provide
pharmacokinetic parameters of PRN action in IH for clinic. (IJCEM1304009).
Keywords: Infantile hemangioma, propranolol, pharmacokinetics, RP-HPLC
Address correspondence to: Dr. Jia Wei Zheng, Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of
Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. E-
mail: davidzhengjw@sjtu.edu.cn
Original Article
Preliminary study on plasma RPN concentration of patients with infantile
hemangioma treated with propranolol
Ling Zhang, Hua-Ming Mai, Jing Zheng, Jia-Wei Zheng, Zheng-Gang Chen, Yan-An Wang, Zhong-Ping Qin, Ke-Lei Li, Wei-En Yuan
Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School
of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, PR China; Laboratory of Molecular Neuropharmacology,
School of Pharmacy East China University of Science and Technology 130 Meilong Road, Shanghai, 200237, PR China; Special
Department of Vascular Anomalies, Linyi Tumor Hospital, Linyi 276000, Shandong Province, PR China; School of Pharmacy, Shanghai
Jiao Tong University, Shanghai 200011, PR China; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi
Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, PR China. Co-first author.
Received April 19, 2013; Accepted May 4, 2013; Epub May 22, 2013; Published June 1, 2013
Abstract: Propranolol (PRN) has recently been recommended as the first-line medicine for complicated infantile hemangiomas (IHs),
because of the significant effect. However, no pharmacokinetic parameters have ever been reported for infants who receive PRN
treatment for IH. In this study, we show that plasma PRN concentration is affected by the frequency of administration of PRN. A single
daily administration of PRN (1 mg/kg/d) resulted in an early elevation of plasma PRN compared to a twice a day administration of the
same dose. In contrast, the twice a day application resulted in a more prolonged expression at a later time-point. Our findings provide
pharmacokinetic parameters of PRN action in IH for clinic. (IJCEM1304009).
Keywords: Infantile hemangioma, propranolol, pharmacokinetics, RP-HPLC
Address correspondence to: Dr. Jia Wei Zheng, Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of
Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. E-
mail: davidzhengjw@sjtu.edu.cn
