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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(4):275-281
Original Article
Screening for high risk human papilloma virus (HR-HPV) subtypes, among
Sudanese patients with oral lesions
Ali Yousif Babiker, Faris Margani Eltom, Mohamed S Abdalaziz, Arshad Rahmani, Saadalnour Abusail, Hussain Gadelkareem Ahmed
Department of Histopathology and Cytology, College of Medical Laboratories Science, Sudan University for Sciences and Technology,
Sudan; Department of Medical laboratory science, College of Applied Medical Sciences, Qassim University, KSA; Department of
Histopathology and Cytology, Faculty of Medical Laboratory Sciences, Elneelain University, Khartoum, Sudan; Department of
Histopathology and Cytology, Facul-ty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
Received March 14, 2013; Accepted March 29, 2013; Epub April 12, 2013; Published April 30, 2013
Abstract: HR-HPV subtypes are strongly linked to etiology of many human cancers including oral cancer. The epidemiology of infection
with different HPV genotypes greatly varies in different countries. The aim of this study was to identify and genotype the HR-HPV
subtypes in oral tissues obtained from Sudanese patients with oral lesions. In this retrospective study 200 patients with oral lesions
were screened by molecular methods (PCR) for the presence of HR-HPV subtypes. Of the 200 patients, 100/200 were patients with
oral cancer (ascertained as case group) and 100/200 were patients with non-neoplastic oral lesions (ascertained as control group).
Out of the 200 patients, 12/200 (6%) were found with HR-HPV infection. Of the 12 positive patients, 8/12 (66.7%) were among cases
and the remaining 4/12 (33.3%) were among control group. The distribution of different genotypes was: type HPV 16 6/12 (50%), HPV18
4/12 (34%), HPV 31 1/12 (8%) and HPV 33 1/12 (8%). In view of these findings, HPV particularly subtypes 16 and 18 play a role in the
etiology of oral cancer in the Sudan. (IJCEM1303009).
Keywords: Oral lesions, HR- HPV, PCR, Toombak, smoking
Address correspondence to: Ali Yousif Yahia Babiker, Sudan University for Sciences and Technology, College of Medical Laboratories,
Department of Histopathology and Cytology, Khartoum, Sudan. E-mail: alibabkr99@gmail.com
Original Article
Screening for high risk human papilloma virus (HR-HPV) subtypes, among
Sudanese patients with oral lesions
Ali Yousif Babiker, Faris Margani Eltom, Mohamed S Abdalaziz, Arshad Rahmani, Saadalnour Abusail, Hussain Gadelkareem Ahmed
Department of Histopathology and Cytology, College of Medical Laboratories Science, Sudan University for Sciences and Technology,
Sudan; Department of Medical laboratory science, College of Applied Medical Sciences, Qassim University, KSA; Department of
Histopathology and Cytology, Faculty of Medical Laboratory Sciences, Elneelain University, Khartoum, Sudan; Department of
Histopathology and Cytology, Facul-ty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
Received March 14, 2013; Accepted March 29, 2013; Epub April 12, 2013; Published April 30, 2013
Abstract: HR-HPV subtypes are strongly linked to etiology of many human cancers including oral cancer. The epidemiology of infection
with different HPV genotypes greatly varies in different countries. The aim of this study was to identify and genotype the HR-HPV
subtypes in oral tissues obtained from Sudanese patients with oral lesions. In this retrospective study 200 patients with oral lesions
were screened by molecular methods (PCR) for the presence of HR-HPV subtypes. Of the 200 patients, 100/200 were patients with
oral cancer (ascertained as case group) and 100/200 were patients with non-neoplastic oral lesions (ascertained as control group).
Out of the 200 patients, 12/200 (6%) were found with HR-HPV infection. Of the 12 positive patients, 8/12 (66.7%) were among cases
and the remaining 4/12 (33.3%) were among control group. The distribution of different genotypes was: type HPV 16 6/12 (50%), HPV18
4/12 (34%), HPV 31 1/12 (8%) and HPV 33 1/12 (8%). In view of these findings, HPV particularly subtypes 16 and 18 play a role in the
etiology of oral cancer in the Sudan. (IJCEM1303009).
Keywords: Oral lesions, HR- HPV, PCR, Toombak, smoking
Address correspondence to: Ali Yousif Yahia Babiker, Sudan University for Sciences and Technology, College of Medical Laboratories,
Department of Histopathology and Cytology, Khartoum, Sudan. E-mail: alibabkr99@gmail.com
