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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(4):310-319
Original Article
Association between thrombelastography system and thromboem-bolic and
bleeding events in Chinese aged people
Jie Bai, Qi-Wen Zheng, Shu-Hong Fu, Xiao-Xia Li, Yu-Ru Li, Yu Zhou, Ji-Hong Yu, Mei-Liang Gong, Da-Fang Chen
Nanlou Clinical Lab, Chinese PLA General Hospital, Beijing 100853, China; Department of Epidemiology and Biostatistics, School of
Public Health, Peking University Health Science Center, Beijing 100191, China. Contributed equally to this work.
Received March 19, 2013; Accepted April 3, 2013; Epub April 12, 2013; Published April 30, 2013
Abstract: Objectives: This study was designed to obtain the knowledge about TEG indexes distribution in Chinese aged people, as
well as to test the hypothesis that previous TEG indexes are associated with the subsequent thromboembolic and bleeding events in
the aged popula-tion. Methods: We conducted a two-year follow-up study in Chinese PLA General Hospital, Beijing, China. 403 aged
people were enrolled in our study. They received TEG measurements at least once when they entered this study. We collected their
demographical characteristics, clinical examination information and their outcome during their observational period. Structural equation
modeling (SEM) was used to analyze the relationship between the four indexes from TEG and the outcome via a pathway of indicator.
Results: We found that in the “model of bleeding” (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df =
9.555/7, CFI was 0.997, TLI was 0.994 and standardized root mean square residual (SRMR) was 0.034; while in the “model of
thromboembolic events” (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df = 6.070/7, CFI was1.000,
TLI was 1.002 and standardized root mean square residual (SRMR) was 0.000. The “model of thromboembolic events” showed that
the four indexes (R, K, MA and ANGLE) were all significantly associated with thromboembolic events, while this significance was not
found in the “model of bleeding”. Conclusions: Previous TEG indexes are significantly associated with the subsequent thromboembolic
events in the aged population. Future study can test this association and provide more information for the clinical use. (IJCEM1303008).
Keywords: Thrombelastography (TEG), thromboembolic event, bleeding, Chinese aged population, structural equation modeling (SEM)
Address correspondence to: Dr. Da-Fang Chen, Department of Epidemiology and Biostatistics, Peking University Health Science
Center, 38 Xue Yuan Road, Haidian District Beijing, 100191, China. Tel: 86-10-8280-2644; Fax: 86-10-8280-2644; E-mail:
dafangchen@bjmu.edu.cn
Original Article
Association between thrombelastography system and thromboem-bolic and
bleeding events in Chinese aged people
Jie Bai, Qi-Wen Zheng, Shu-Hong Fu, Xiao-Xia Li, Yu-Ru Li, Yu Zhou, Ji-Hong Yu, Mei-Liang Gong, Da-Fang Chen
Nanlou Clinical Lab, Chinese PLA General Hospital, Beijing 100853, China; Department of Epidemiology and Biostatistics, School of
Public Health, Peking University Health Science Center, Beijing 100191, China. Contributed equally to this work.
Received March 19, 2013; Accepted April 3, 2013; Epub April 12, 2013; Published April 30, 2013
Abstract: Objectives: This study was designed to obtain the knowledge about TEG indexes distribution in Chinese aged people, as
well as to test the hypothesis that previous TEG indexes are associated with the subsequent thromboembolic and bleeding events in
the aged popula-tion. Methods: We conducted a two-year follow-up study in Chinese PLA General Hospital, Beijing, China. 403 aged
people were enrolled in our study. They received TEG measurements at least once when they entered this study. We collected their
demographical characteristics, clinical examination information and their outcome during their observational period. Structural equation
modeling (SEM) was used to analyze the relationship between the four indexes from TEG and the outcome via a pathway of indicator.
Results: We found that in the “model of bleeding” (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df =
9.555/7, CFI was 0.997, TLI was 0.994 and standardized root mean square residual (SRMR) was 0.034; while in the “model of
thromboembolic events” (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df = 6.070/7, CFI was1.000,
TLI was 1.002 and standardized root mean square residual (SRMR) was 0.000. The “model of thromboembolic events” showed that
the four indexes (R, K, MA and ANGLE) were all significantly associated with thromboembolic events, while this significance was not
found in the “model of bleeding”. Conclusions: Previous TEG indexes are significantly associated with the subsequent thromboembolic
events in the aged population. Future study can test this association and provide more information for the clinical use. (IJCEM1303008).
Keywords: Thrombelastography (TEG), thromboembolic event, bleeding, Chinese aged population, structural equation modeling (SEM)
Address correspondence to: Dr. Da-Fang Chen, Department of Epidemiology and Biostatistics, Peking University Health Science
Center, 38 Xue Yuan Road, Haidian District Beijing, 100191, China. Tel: 86-10-8280-2644; Fax: 86-10-8280-2644; E-mail:
dafangchen@bjmu.edu.cn
