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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(4):289-295
Original Article
HDFx: a novel biologic immunomodulator accelerates wound healing and is
suggestive of unique regenerative powers: potential implications for the warfighter
and disaster victims
Burton M Altura, Anthony Carella, Asefa Gebrewold
Department of Physiology and Pharmacology; Department of Medicine; The Center for Cardiovascular and Muscle Research; The
School of Graduate Studies Program in Molecular and Cellular Science, State University of New York, Downstate Medical Center,
Brooklyn, New York 11203; 5Bio-Defense Systems, Inc, Rockville Centre, New York 11570, USA; 6Oceanica Biomedica, Estero, Florida
33928
Received May 24, 2012; Accepted June 26, 2012; Epub August 22, 2012; Published September 15, 2012
Abstract: Recently, we reported on the discovery of a new, conserved biologic protein (35-40 KDa), termed HDFx, that protects rats,
guinea-pigs, mice, and rabbits against lethal hemorrhage, endotoxins, intestinal ischemic-shock, and traumatic injuries. It was found
to stimulate several arms of the immune system. The present report demonstrates, for the first time, that HDFx accelerates wound
healing in two different models (excision wound model; and incision wound model) in rats. The results shown, herein, indicate that
HDFx produces greater rates of wound contraction, greater tensile strength, and more rapid healing than controls. Our new data also
show that this biologic increases hydroxyproline content of granulation tissue coupled with a reduction in superoxide dismutase (SOD).
In addition, we show that HDFx increases the levels of serum ascorbic acid and stimulates the mononuclear cells of the
reticuloendothelial system (RES). Overall, these data suggest that HDFx may possess unique regenerative powers. We, thus, believe
that HDFx can be of great potential use in diverse types of wounds which, otherwise, could result in difficult to treat infections and thus
prevent sepsis and loss of body parts from amputations. (IJCEM1205005).
Keywords: Wound contraction, tensile strength, wound healing, hydroxyproline, SOD, reticuloendothelial system
Address all correspondence to:
Dr. Altura B M
SUNY Downstate Medical Center
Box 31, 450 Clarkson Avenue
Brooklyn, NY 11203, USA.
Tel: 718-270-2194; Fax: 718-270-3103
E-mail: baltura@downstate.edu
Original Article
HDFx: a novel biologic immunomodulator accelerates wound healing and is
suggestive of unique regenerative powers: potential implications for the warfighter
and disaster victims
Burton M Altura, Anthony Carella, Asefa Gebrewold
Department of Physiology and Pharmacology; Department of Medicine; The Center for Cardiovascular and Muscle Research; The
School of Graduate Studies Program in Molecular and Cellular Science, State University of New York, Downstate Medical Center,
Brooklyn, New York 11203; 5Bio-Defense Systems, Inc, Rockville Centre, New York 11570, USA; 6Oceanica Biomedica, Estero, Florida
33928
Received May 24, 2012; Accepted June 26, 2012; Epub August 22, 2012; Published September 15, 2012
Abstract: Recently, we reported on the discovery of a new, conserved biologic protein (35-40 KDa), termed HDFx, that protects rats,
guinea-pigs, mice, and rabbits against lethal hemorrhage, endotoxins, intestinal ischemic-shock, and traumatic injuries. It was found
to stimulate several arms of the immune system. The present report demonstrates, for the first time, that HDFx accelerates wound
healing in two different models (excision wound model; and incision wound model) in rats. The results shown, herein, indicate that
HDFx produces greater rates of wound contraction, greater tensile strength, and more rapid healing than controls. Our new data also
show that this biologic increases hydroxyproline content of granulation tissue coupled with a reduction in superoxide dismutase (SOD).
In addition, we show that HDFx increases the levels of serum ascorbic acid and stimulates the mononuclear cells of the
reticuloendothelial system (RES). Overall, these data suggest that HDFx may possess unique regenerative powers. We, thus, believe
that HDFx can be of great potential use in diverse types of wounds which, otherwise, could result in difficult to treat infections and thus
prevent sepsis and loss of body parts from amputations. (IJCEM1205005).
Keywords: Wound contraction, tensile strength, wound healing, hydroxyproline, SOD, reticuloendothelial system
Address all correspondence to:
Dr. Altura B M
SUNY Downstate Medical Center
Box 31, 450 Clarkson Avenue
Brooklyn, NY 11203, USA.
Tel: 718-270-2194; Fax: 718-270-3103
E-mail: baltura@downstate.edu
