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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(2):145-153
Original Article
24-Hour ambulatory blood pressure associates inversely with prostaglandin F2α,
interleukin-6 and F2-isoprostane formation in a Swedish population of older men
Johanna Helmersson-Karlqvist, Kristina Björklund-Bodegård, Anders Larsson, Samar Basu
Clinical Chemistry/Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; Oxidative stress and inflammation/Public Health
and Caring Sciences, Uppsala University, and Centre of Excellence-Inflammation, Uppsala University Hospital, Uppsala, Sweden;
Geriatrics/Public Health and Caring Sciences, Uppsala University, Uppsala Sweden; Laboratory of Biochemistry, Molecular Biology and
Nutrition, Faculty of Pharmacy, University d’Auvergne, Clermont-Ferrand, France
Received February 3, 2012; accepted March 6, 2012; Epub April 6, 2012; Published April 30, 2012
Abstract: Vasoconstrictive prostaglandins (PGs), such as PGF2α or F2-isoprostanes, and systemic inflammation may be involved in
the physiological regulation of blood pressure (BP) and the pathophysiology leading to hypertension. However studies evaluating these
parameters and BP in human populations are sparse. We analysed the cross-sectional associations between 24-hour ambulatory BP
and urinary 15-keto-dihydro-PGF2α (indicator of PG-mediated vasoconstriction and inflammation), plasma interleukin-6 (IL-6), C-
reactive protein (CRP), serum amyloid A (SAA) and urinary F2-isoprostanes (indicator of vasoconstriction and oxidative stress) in 619
men in a Swedish older population (Uppsala Longitudinal Study of Adult Men, age 78 years). Both systolic and diastolic 24-hour BP
correlated inversely with concentrations of 15-keto-dihydro-PGF2α P<0.01) and F2-isoprostanes (P<0.01) independent on other
cardiovascular risk factors. Additionally, diastolic 24-hour BP inversely correlated with plasma IL-6 (P<0.05) and 24-hour pulse
pressure showed a positive linear correlation with IL-6, CRP and SAA. In conclusion, high BP is associated with decreased formation
of vasoconstrictive PGF2α and F2-isoprostanes in this population of older men. These findings, although unlike our original
hypothesis, might have an important physiological function which needs to be further evaluated. (IJCEM1202002).
Keywords: Blood pressure, pulse pressure, eicosanoids, prostaglandin F2α, F2-isoprostanes, interleukin-6, inflammation, human,
population
Address all correspondence to:
Dr Johanna Helmersson Karlqvist
Clinical, Chemistry/Medical Sciences
Uppsala University Hospital
SE-751 85 Uppsala, Sweden.
Tel: +46 18 611 42 28; Fax: +46 18 552562
E-mail: johanna.helmersson_karlqvist@medsci.uu.se
Original Article
24-Hour ambulatory blood pressure associates inversely with prostaglandin F2α,
interleukin-6 and F2-isoprostane formation in a Swedish population of older men
Johanna Helmersson-Karlqvist, Kristina Björklund-Bodegård, Anders Larsson, Samar Basu
Clinical Chemistry/Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; Oxidative stress and inflammation/Public Health
and Caring Sciences, Uppsala University, and Centre of Excellence-Inflammation, Uppsala University Hospital, Uppsala, Sweden;
Geriatrics/Public Health and Caring Sciences, Uppsala University, Uppsala Sweden; Laboratory of Biochemistry, Molecular Biology and
Nutrition, Faculty of Pharmacy, University d’Auvergne, Clermont-Ferrand, France
Received February 3, 2012; accepted March 6, 2012; Epub April 6, 2012; Published April 30, 2012
Abstract: Vasoconstrictive prostaglandins (PGs), such as PGF2α or F2-isoprostanes, and systemic inflammation may be involved in
the physiological regulation of blood pressure (BP) and the pathophysiology leading to hypertension. However studies evaluating these
parameters and BP in human populations are sparse. We analysed the cross-sectional associations between 24-hour ambulatory BP
and urinary 15-keto-dihydro-PGF2α (indicator of PG-mediated vasoconstriction and inflammation), plasma interleukin-6 (IL-6), C-
reactive protein (CRP), serum amyloid A (SAA) and urinary F2-isoprostanes (indicator of vasoconstriction and oxidative stress) in 619
men in a Swedish older population (Uppsala Longitudinal Study of Adult Men, age 78 years). Both systolic and diastolic 24-hour BP
correlated inversely with concentrations of 15-keto-dihydro-PGF2α P<0.01) and F2-isoprostanes (P<0.01) independent on other
cardiovascular risk factors. Additionally, diastolic 24-hour BP inversely correlated with plasma IL-6 (P<0.05) and 24-hour pulse
pressure showed a positive linear correlation with IL-6, CRP and SAA. In conclusion, high BP is associated with decreased formation
of vasoconstrictive PGF2α and F2-isoprostanes in this population of older men. These findings, although unlike our original
hypothesis, might have an important physiological function which needs to be further evaluated. (IJCEM1202002).
Keywords: Blood pressure, pulse pressure, eicosanoids, prostaglandin F2α, F2-isoprostanes, interleukin-6, inflammation, human,
population
Address all correspondence to:
Dr Johanna Helmersson Karlqvist
Clinical, Chemistry/Medical Sciences
Uppsala University Hospital
SE-751 85 Uppsala, Sweden.
Tel: +46 18 611 42 28; Fax: +46 18 552562
E-mail: johanna.helmersson_karlqvist@medsci.uu.se
