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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(2):179-185
Original Article
Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
Alexander Arutjunyan, Lyudmila Kozina, Sergey Stvolinskiy, Yelena Bulygina, Anna Mashkina, Vladimir Khavinson
D.O. Ott Institute of Obstetrics and Gynecology, NWB RAMS, St. Petersburg, Russia, Institute of Bioregulation and Gerontology, NWB
RAMS, St. Petersburg, Russia; Laboratory of Clinical and Experimental Neurochemistry, Research Center of Neurology, RAMS,
Moscow, Russia, 4Department of Biochemistry, M.V. Lomonosov State University, Moscow, Russia
Received November 25, 2011; accepted January 20, 2012; Epub April 6, 2012; Published April 30, 2012
Abstract: The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within
pregnancy has been studied. Using pinealon (Glu-Asp-Arg) under these conditions was found to result in the offspring cognitive
function being improved significantly and their cerebellum neurons becoming more resistant to oxidative stress. This may be proved by
the fact that the administration of pinealon to pregnant rats loaded with methionine improved their offspring spatial orientation and
learning ability and decreased both reactive oxygen species accumulation and the number of necrotic cells in the population of the
neurons isolated from the cerebellum of the offspring developed under the prenatal hyperhomocysteinemia. Our experiments allowed
confirming the neuroprotective properties of pinealon, which is in agreement with the previous data obtained by us in vitro.
(IJCEM1111007).
Keywords: Prenatal hyperhomocysteinemia, rat offspring, oxidative stress, neuroprotection, pinealon
Address all correspondence to:
Dr. Arutjunyan Alexander
Department of Biochemistry
D.O. Ott Institute of Obstetrics and Gynecology
Russian Academy of Medical Sciences
St. Petersburg, 199 034, Russia.
Tel./ Fax. +7 (812) 328 98 91
E-mail: arutjunyan@aa3703.spb.edu
Original Article
Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
Alexander Arutjunyan, Lyudmila Kozina, Sergey Stvolinskiy, Yelena Bulygina, Anna Mashkina, Vladimir Khavinson
D.O. Ott Institute of Obstetrics and Gynecology, NWB RAMS, St. Petersburg, Russia, Institute of Bioregulation and Gerontology, NWB
RAMS, St. Petersburg, Russia; Laboratory of Clinical and Experimental Neurochemistry, Research Center of Neurology, RAMS,
Moscow, Russia, 4Department of Biochemistry, M.V. Lomonosov State University, Moscow, Russia
Received November 25, 2011; accepted January 20, 2012; Epub April 6, 2012; Published April 30, 2012
Abstract: The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within
pregnancy has been studied. Using pinealon (Glu-Asp-Arg) under these conditions was found to result in the offspring cognitive
function being improved significantly and their cerebellum neurons becoming more resistant to oxidative stress. This may be proved by
the fact that the administration of pinealon to pregnant rats loaded with methionine improved their offspring spatial orientation and
learning ability and decreased both reactive oxygen species accumulation and the number of necrotic cells in the population of the
neurons isolated from the cerebellum of the offspring developed under the prenatal hyperhomocysteinemia. Our experiments allowed
confirming the neuroprotective properties of pinealon, which is in agreement with the previous data obtained by us in vitro.
(IJCEM1111007).
Keywords: Prenatal hyperhomocysteinemia, rat offspring, oxidative stress, neuroprotection, pinealon
Address all correspondence to:
Dr. Arutjunyan Alexander
Department of Biochemistry
D.O. Ott Institute of Obstetrics and Gynecology
Russian Academy of Medical Sciences
St. Petersburg, 199 034, Russia.
Tel./ Fax. +7 (812) 328 98 91
E-mail: arutjunyan@aa3703.spb.edu
