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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2011;4(1):17-25
Review Article
Crude drugs as anticancer agents
Xiaoyang Mou, Santosh Kesari, Patrick Y. Wen, Xudong Huang
Conjugate and Medicinal Chemistry Laboratory, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology,
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA; Moores Cancer Center, University of California
San Diego, La Jolla, CA 92093, USA; Department of Medical Oncology, Dana-Faber Cancer Institute, Department of Neurology,
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Received November 12, 2010; accepted November 25, 2010; Epub December 3, 2010; published January 1, 2011
Abstract: Although tremendous progresses have been made in basic cancer biology and in the development of novel cancer
treatments, cancer remains a leading cause of death in the world. The etiopathogenesis of cancer is complex. Besides genetic
predisposition, known environmental factors associated with cancer are: diet, lifestyle, and environmental toxins. Toxicity of drugs and
eventual relapse of cancers contribute to high cancer death rates. Current therapeutic interventions for cancer- surgery, chemotherapy,
radiotherapy, thermotherapy, etc. are far from being curative for many forms of cancer. Chemotherapy, in particular, though the most
commonly used cancer treatment, is usually associated with side effects with varying degrees of severity. The purpose of this brief
review is to assemble current literature data on some crude drugs and to focus on their beneficial roles and drug targets in cancer
therapy and chemoprevention. Although their pharmacological mechanisms and biochemical roles in cancer biology and tumor
chemoprevention are not fully understood, crude drugs are believed to have nutriceutical effects upon cancer patients. (IJCEM1011002).
Keywords: Crude drug, cancer, inflammation, cell cycle, apoptosis
Full Text PDF
Address all correspondence to:
Xudong Huang, PhD
Conjugate and Medicinal Chemistry Laboratory
Division of Nuclear Medicine and Molecular Imaging
Department of Radiology
Brigham and Women’s Hospital and Harvard Medical School
Boston, MA 02115, USA.
Telephone: 617-582-4711; Fax: 617-582-0004
E-mail: xhuang3@partners.org
Review Article
Crude drugs as anticancer agents
Xiaoyang Mou, Santosh Kesari, Patrick Y. Wen, Xudong Huang
Conjugate and Medicinal Chemistry Laboratory, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology,
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA; Moores Cancer Center, University of California
San Diego, La Jolla, CA 92093, USA; Department of Medical Oncology, Dana-Faber Cancer Institute, Department of Neurology,
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Received November 12, 2010; accepted November 25, 2010; Epub December 3, 2010; published January 1, 2011
Abstract: Although tremendous progresses have been made in basic cancer biology and in the development of novel cancer
treatments, cancer remains a leading cause of death in the world. The etiopathogenesis of cancer is complex. Besides genetic
predisposition, known environmental factors associated with cancer are: diet, lifestyle, and environmental toxins. Toxicity of drugs and
eventual relapse of cancers contribute to high cancer death rates. Current therapeutic interventions for cancer- surgery, chemotherapy,
radiotherapy, thermotherapy, etc. are far from being curative for many forms of cancer. Chemotherapy, in particular, though the most
commonly used cancer treatment, is usually associated with side effects with varying degrees of severity. The purpose of this brief
review is to assemble current literature data on some crude drugs and to focus on their beneficial roles and drug targets in cancer
therapy and chemoprevention. Although their pharmacological mechanisms and biochemical roles in cancer biology and tumor
chemoprevention are not fully understood, crude drugs are believed to have nutriceutical effects upon cancer patients. (IJCEM1011002).
Keywords: Crude drug, cancer, inflammation, cell cycle, apoptosis
Full Text PDF
Address all correspondence to:
Xudong Huang, PhD
Conjugate and Medicinal Chemistry Laboratory
Division of Nuclear Medicine and Molecular Imaging
Department of Radiology
Brigham and Women’s Hospital and Harvard Medical School
Boston, MA 02115, USA.
Telephone: 617-582-4711; Fax: 617-582-0004
E-mail: xhuang3@partners.org
