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Int J Clin Exp Med 2011;4(1):10-16
Original Article
Multiple different laminar velocity profiles in separate veins in the microvascular
network of brain cortex in rats
Yalikun Mutalifu, Lovisa Holm, Can Ince, Elvar Theodorsson, Folke Sjöberg
Departments of Clinical and Experimental Medicine (Intensive Care and Plastic surgery/Clinical Chemistry), Faculty of Health sciences,
Linköping University /University Hospital, S-581 85 Linköping, Sweden; Department of Intensive Care, Erasmus Medical Center,
Erasmus University of Rotterdam, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; The burn unit, Department of Plastic
surgery, Urumchi Friendship Hospital,Xinjiang China.
Received November 2, 2010; accepted November 30, 2010; Epub December 2, 2010; published January 1, 2011
Abstract: The orthogonal polarisation spectral (OPS) imaging technique is a method that enables intravital microscopy of the tissue
microvasculature particularly including the erythrocytes and leucocytes. As a new finding we here report multi flow, i.e, several different
laminar velocity profiles in each and separate veins (diameters < 200 μm) of the microcirculation of the rat brain cortex. The
phenomenon was present in all 20 preparations studied and these different laminar velocity profiles were regularly maintained in
length beyond 20 times the diameter of parent vessel. In single veins up to 9 different laminar velocity profiles were discernible, each
with a different red blood cell velocity. These multi flow profiles may theoretically be anticipated based on what is known in rheological
physiology as the Fåhreus - Lindqvist effect. It may also be predicted in tissues that have both high and heterogeneous blood flows in
conjunction with large local variations in metabolic activity as are present in the cortex of the brain. The new information is that the extent
and magnitude of this multi laminar flow phenomenon especially in the venular network of the brain exceeds what has previously been
known. The physiological importance of these finding warrants further studies. (IJCEM1011001).
Keywords: Dynamic structure of blood flow, multi-laminar flow profiles, orthogonal polarization spectral imaging, rheology
Full Text PDF
Address all correspondence to:
Folke Sjöberg, MD, PhD
Depts. of Hand and Plastic Surgery and Intensive care,
Linköping University Hospital,
581 85 Linköping
Sweden
Tel: 46 13 22 1820
Fax: +46 13 22 2836
E-mail: folsj@ibk.liu.se
Original Article
Multiple different laminar velocity profiles in separate veins in the microvascular
network of brain cortex in rats
Yalikun Mutalifu, Lovisa Holm, Can Ince, Elvar Theodorsson, Folke Sjöberg
Departments of Clinical and Experimental Medicine (Intensive Care and Plastic surgery/Clinical Chemistry), Faculty of Health sciences,
Linköping University /University Hospital, S-581 85 Linköping, Sweden; Department of Intensive Care, Erasmus Medical Center,
Erasmus University of Rotterdam, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; The burn unit, Department of Plastic
surgery, Urumchi Friendship Hospital,Xinjiang China.
Received November 2, 2010; accepted November 30, 2010; Epub December 2, 2010; published January 1, 2011
Abstract: The orthogonal polarisation spectral (OPS) imaging technique is a method that enables intravital microscopy of the tissue
microvasculature particularly including the erythrocytes and leucocytes. As a new finding we here report multi flow, i.e, several different
laminar velocity profiles in each and separate veins (diameters < 200 μm) of the microcirculation of the rat brain cortex. The
phenomenon was present in all 20 preparations studied and these different laminar velocity profiles were regularly maintained in
length beyond 20 times the diameter of parent vessel. In single veins up to 9 different laminar velocity profiles were discernible, each
with a different red blood cell velocity. These multi flow profiles may theoretically be anticipated based on what is known in rheological
physiology as the Fåhreus - Lindqvist effect. It may also be predicted in tissues that have both high and heterogeneous blood flows in
conjunction with large local variations in metabolic activity as are present in the cortex of the brain. The new information is that the extent
and magnitude of this multi laminar flow phenomenon especially in the venular network of the brain exceeds what has previously been
known. The physiological importance of these finding warrants further studies. (IJCEM1011001).
Keywords: Dynamic structure of blood flow, multi-laminar flow profiles, orthogonal polarization spectral imaging, rheology
Full Text PDF
Address all correspondence to:
Folke Sjöberg, MD, PhD
Depts. of Hand and Plastic Surgery and Intensive care,
Linköping University Hospital,
581 85 Linköping
Sweden
Tel: 46 13 22 1820
Fax: +46 13 22 2836
E-mail: folsj@ibk.liu.se
