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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2010;3(2):110-114
Original Article
Photodynamic therapy induces interleukin secretion from dendritic cells
Toshihiro Kushibiki, Takako Tajiri, Yutaka Tomioka, Kunio Awazu
Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan;
Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka,
Suita, Osaka, 565-0871, Japan.
Received February 25, 2010, accepted March 26, 2010, available online April 25, 2010
Abstract: Dendritic cells (DC) pulsed with tumor-derived peptides, proteins, genes, or lysates have been studied as therapeutic cancer
vaccines. However, the overall therapeutic efficacy of this approach has been limited, indicating a need to either enhance its potency or
combine it with other treatment modalities. Photodynamic therapy (PDT) process consists of injecting a photosensitizer, which
selectively accumulates at the lesion site, followed by local illumination of the tumor with a laser of the appropriate wavelength to
activate the specific drug. PDT has the potential to create an environment at the tumor site that favors both tumor antigen loading and
activation of DCs, key requirements for induction of antitumor immunity. Here, we report that PDT can induce IL-1 and IL-6 and reduce
TNF-alpha expression from DCs. This finding has potentially broad clinical implications since these changes are mechanistically
involved in the observed effects of PDT on host immune responses. Not all tumors are amenable to PDT, either because of size or
location, and one could conceive of an adjuvant use for PDT vaccines in conjunction with other cancer modalities that do not enhance
the host antitumor immune response. (IJCEM1002002).
Key words: Photodynamic therapy, dendritic cells, tumor immunity, interleukin
Full Text PDF
Address all correspondence to:
Toshihiro Kushibiki, PhD
Frontier Research Center
Graduate School of Engineering
Osaka University
2-1 Yamadaoka, Suita
Osaka, 565-0871, Japan
E-mail: kushibiki@see.eng.osaka-u.ac.jp
Original Article
Photodynamic therapy induces interleukin secretion from dendritic cells
Toshihiro Kushibiki, Takako Tajiri, Yutaka Tomioka, Kunio Awazu
Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan;
Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka,
Suita, Osaka, 565-0871, Japan.
Received February 25, 2010, accepted March 26, 2010, available online April 25, 2010
Abstract: Dendritic cells (DC) pulsed with tumor-derived peptides, proteins, genes, or lysates have been studied as therapeutic cancer
vaccines. However, the overall therapeutic efficacy of this approach has been limited, indicating a need to either enhance its potency or
combine it with other treatment modalities. Photodynamic therapy (PDT) process consists of injecting a photosensitizer, which
selectively accumulates at the lesion site, followed by local illumination of the tumor with a laser of the appropriate wavelength to
activate the specific drug. PDT has the potential to create an environment at the tumor site that favors both tumor antigen loading and
activation of DCs, key requirements for induction of antitumor immunity. Here, we report that PDT can induce IL-1 and IL-6 and reduce
TNF-alpha expression from DCs. This finding has potentially broad clinical implications since these changes are mechanistically
involved in the observed effects of PDT on host immune responses. Not all tumors are amenable to PDT, either because of size or
location, and one could conceive of an adjuvant use for PDT vaccines in conjunction with other cancer modalities that do not enhance
the host antitumor immune response. (IJCEM1002002).
Key words: Photodynamic therapy, dendritic cells, tumor immunity, interleukin
Full Text PDF
Address all correspondence to:
Toshihiro Kushibiki, PhD
Frontier Research Center
Graduate School of Engineering
Osaka University
2-1 Yamadaoka, Suita
Osaka, 565-0871, Japan
E-mail: kushibiki@see.eng.osaka-u.ac.jp
