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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2010;3(2):115-121
Original Article
Hypocalcitonemia in Handigodu Disease: a spondylo epi (meta) physeal dysplasia
Mallikarjun Badadani, K. Taranath Shetty, S.S.Agarwal
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore-560029, India.
Received January 17, 2010; accepted March 22, 2010, available online March 26, 2010
Abstract: Handigodu Disease (HD) is a disorder of the osteoarticular system which is highly prevalent in several villages of two
districts viz, Shimoga and Chikmaglur of the state of Karnataka, southern India. The scientific name of the disease is
Spondylo-epi-(meta) physeal Dysplasia, Autosomal Dominant variety, Handigodu syndrome. The same has been listed in the
International Classification of Skeletal Dysplasias. The calcium homeostasis study was lack in HD. The serum calcium, phosphorus,
parathyroid hormone and calcitonin levels after overnight fast state, and 24 hour urinary excretion of calcium and phosphorus were
quantified. The decreased level of calcitonin associated with decreased serum total calcium and urinary calcium in HD were observed.
The levels of parathyroid hormone, serum phosphorus and urinary phosphorus remain unchanged among HD affected. The Vitamin
D3 levels also noticed unchanged in HD affected. Since calcitonin has antiresorption effect on bone, the observed low calcitonin in HD
may imply reosrption of bone leading to deformity and causes hypocalcaemia and hypocalciuria. The hypocalcitonemia without change
in iPTH associated with hypocalcaemia may be a mutation in Vit D receptor (VDR) or may be an epiphenomenon. (IJCEM1001003).
Keywords: Calcitonin, hypocalciuria, parathyroid hormone
Full Text PDF
Address all correspondence to:
Mallikarjun Badadani PhD
University of California, Irvine
2501, Hewitt Hall, Irvine
CA-92697
Tel: 1-903-618-9413
Fax: (949)824-6388
E-mail: badadani@gmail.com
Original Article
Hypocalcitonemia in Handigodu Disease: a spondylo epi (meta) physeal dysplasia
Mallikarjun Badadani, K. Taranath Shetty, S.S.Agarwal
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore-560029, India.
Received January 17, 2010; accepted March 22, 2010, available online March 26, 2010
Abstract: Handigodu Disease (HD) is a disorder of the osteoarticular system which is highly prevalent in several villages of two
districts viz, Shimoga and Chikmaglur of the state of Karnataka, southern India. The scientific name of the disease is
Spondylo-epi-(meta) physeal Dysplasia, Autosomal Dominant variety, Handigodu syndrome. The same has been listed in the
International Classification of Skeletal Dysplasias. The calcium homeostasis study was lack in HD. The serum calcium, phosphorus,
parathyroid hormone and calcitonin levels after overnight fast state, and 24 hour urinary excretion of calcium and phosphorus were
quantified. The decreased level of calcitonin associated with decreased serum total calcium and urinary calcium in HD were observed.
The levels of parathyroid hormone, serum phosphorus and urinary phosphorus remain unchanged among HD affected. The Vitamin
D3 levels also noticed unchanged in HD affected. Since calcitonin has antiresorption effect on bone, the observed low calcitonin in HD
may imply reosrption of bone leading to deformity and causes hypocalcaemia and hypocalciuria. The hypocalcitonemia without change
in iPTH associated with hypocalcaemia may be a mutation in Vit D receptor (VDR) or may be an epiphenomenon. (IJCEM1001003).
Keywords: Calcitonin, hypocalciuria, parathyroid hormone
Full Text PDF
Address all correspondence to:
Mallikarjun Badadani PhD
University of California, Irvine
2501, Hewitt Hall, Irvine
CA-92697
Tel: 1-903-618-9413
Fax: (949)824-6388
E-mail: badadani@gmail.com
