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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(4),294-304;2008
Original Article
Regulatory T Cells in Renal Disease
Yuan Min Wang, Min Hu, Ya Wang, Tania Polhill , Geoff Yu Zhang, Yiping Wang, Vincent W.S. Lee, David C.H. Harris and Stephen I
Alexander
Centre for Kidney Research, Children’s Hospital at Westmead, University of Sydney, Westmead NSW 2145 Australia; Centre for
Transplant and Renal Research, University of Sydney at Westmead, Sydney, NSW, Australia
Received July 27, 2008; accepted August 13, 2008; available online August 28, 2008
Abstract: Regulatory T cells (Tregs) have a key role in immune homeostasis and in suppressing unwanted inflammatory responses
toward self-antigens. Tregs have been implicated in the control of initial activation events, and play roles in limiting proliferation,
differentiation and effector functions of T helper cells. However, the activities of Tregs in the development and progression of kidney
disease are not fully elucidated. We have demonstrated the potency of Tregs in animal models of kidney disease. In this review, we
summarise mechanistic information from rodent models on the roles of Tregs in glomerular immunopathology and discuss the
function of Tregs in diverse kidney diseases. Further studies of Tregs should provide important insights into designing of therapeutic
strategies to prevent human kidney disease. (IJCEM807005).
Key Words: Regulatory T cells, Foxp3, renal disease, immunotherapy
Full Text PDF
Address all correspondence to: Yuan Min Wang, PhD, Centre for Kidney Research, Children’s Hospital at Westmead, Westmead
NSW 2145 Australia, Phone: +61 2 9845 3106, Fax: +61 2 9845 3178, E-mail: yuanw@chw.edu.au
Original Article
Regulatory T Cells in Renal Disease
Yuan Min Wang, Min Hu, Ya Wang, Tania Polhill , Geoff Yu Zhang, Yiping Wang, Vincent W.S. Lee, David C.H. Harris and Stephen I
Alexander
Centre for Kidney Research, Children’s Hospital at Westmead, University of Sydney, Westmead NSW 2145 Australia; Centre for
Transplant and Renal Research, University of Sydney at Westmead, Sydney, NSW, Australia
Received July 27, 2008; accepted August 13, 2008; available online August 28, 2008
Abstract: Regulatory T cells (Tregs) have a key role in immune homeostasis and in suppressing unwanted inflammatory responses
toward self-antigens. Tregs have been implicated in the control of initial activation events, and play roles in limiting proliferation,
differentiation and effector functions of T helper cells. However, the activities of Tregs in the development and progression of kidney
disease are not fully elucidated. We have demonstrated the potency of Tregs in animal models of kidney disease. In this review, we
summarise mechanistic information from rodent models on the roles of Tregs in glomerular immunopathology and discuss the
function of Tregs in diverse kidney diseases. Further studies of Tregs should provide important insights into designing of therapeutic
strategies to prevent human kidney disease. (IJCEM807005).
Key Words: Regulatory T cells, Foxp3, renal disease, immunotherapy
Full Text PDF
Address all correspondence to: Yuan Min Wang, PhD, Centre for Kidney Research, Children’s Hospital at Westmead, Westmead
NSW 2145 Australia, Phone: +61 2 9845 3106, Fax: +61 2 9845 3178, E-mail: yuanw@chw.edu.au
