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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(4),310-318;2008
Original Article
Castration Had No Effect on Decreased Expression of the Neural Cell Adhesion
Molecule in the Prefrontal Cortex of Rats Subjected to Chronic Mild Stress
Qian Huang, Hui Liu, Hong Zhu, Jiang-Ning Zhou
Department of Pathology, Army Medical College, National University of Sciences and Technology, Rawalpindi-Pakistan
Received June 16, 2008; accepted August 10, 2008; available online August 15, 2008
Abstract: The effect of chronic mild stress on protein levels of the neural cell adhesion molecule (NCAM) were evaluated in the
prefrontal cortex and hippocampus of rat brain. Decreased NCAM protein expression in the prefrontal cortex was found in the rats
subjected to stress, while the protein levels in sub-regions of hippocampus remained unchanged. The study also explored whether
there was a testicular hormone influence on the behavioral response to stress and on the NCAM expression. We found chronic mild
stress induced an anhedonia-like behavior in intact rats, but not in the castrated male rats. Furthermore, castration did not have
influence on the stress induced reduction of NCAM expression in the prefrontal cortex. In conclusion, our findings indicate that NCAM
mediated remodelling in the prefrontal cortex under chronic mild stress condition might be independent to the sex hormones during the
adult period in male rat. (IJCEM806002).
Key Words: Chronic mild stress (CMS), castration, neural cell adhesion molecule (NCAM), behaviour test, prefrontal cortex (PFC),
hippocampus
Full Text PDF
Address all correspondence to: Jiang-Ning Zhou, MD, PhD, Professor of Neurobiology, Department of Neurobiology and Biophysics,
School of Life Sciennce, USTC, Hefei, Anhui 230027, PR, China, Tel: +86-551-3607658; Fax: +86-551-3600408, E-mail:
jnzhou@ustc.edu.cn
Original Article
Castration Had No Effect on Decreased Expression of the Neural Cell Adhesion
Molecule in the Prefrontal Cortex of Rats Subjected to Chronic Mild Stress
Qian Huang, Hui Liu, Hong Zhu, Jiang-Ning Zhou
Department of Pathology, Army Medical College, National University of Sciences and Technology, Rawalpindi-Pakistan
Received June 16, 2008; accepted August 10, 2008; available online August 15, 2008
Abstract: The effect of chronic mild stress on protein levels of the neural cell adhesion molecule (NCAM) were evaluated in the
prefrontal cortex and hippocampus of rat brain. Decreased NCAM protein expression in the prefrontal cortex was found in the rats
subjected to stress, while the protein levels in sub-regions of hippocampus remained unchanged. The study also explored whether
there was a testicular hormone influence on the behavioral response to stress and on the NCAM expression. We found chronic mild
stress induced an anhedonia-like behavior in intact rats, but not in the castrated male rats. Furthermore, castration did not have
influence on the stress induced reduction of NCAM expression in the prefrontal cortex. In conclusion, our findings indicate that NCAM
mediated remodelling in the prefrontal cortex under chronic mild stress condition might be independent to the sex hormones during the
adult period in male rat. (IJCEM806002).
Key Words: Chronic mild stress (CMS), castration, neural cell adhesion molecule (NCAM), behaviour test, prefrontal cortex (PFC),
hippocampus
Full Text PDF
Address all correspondence to: Jiang-Ning Zhou, MD, PhD, Professor of Neurobiology, Department of Neurobiology and Biophysics,
School of Life Sciennce, USTC, Hefei, Anhui 230027, PR, China, Tel: +86-551-3607658; Fax: +86-551-3600408, E-mail:
jnzhou@ustc.edu.cn
