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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 1(2),154-160;2008
Review Article
RNA Interference as A Potential Therapeutic Treatment for Inflammation Associated
Lung Injury
Joanne Lomas-Neira, Chun-Shiang Chung, Alfred Ayala
Division of Surgical Research, Department of Surgery, Rhode Island Hospital/Warren Alpert School of Medicine at Brown University,
Providence, RI 02903
Received January 3, 2008; accepted January 30, 2008; available online February 25, 2008
Abstract: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain important sources of morbidity for patients in
the ICUs in the developed world. However, imagine having as a therapeutic tool, the ability to regulate, in a tissue specific manner, the
expression of a given gene. RNA interference, as potentially such a method of selectively suppressing protein expression, has evolved
as an important tool in the study of gene specific function and targeted therapeutics. Significant progress has been made in identifying
potential gene targets integral to the pathways leading to the development of inflammation-associated lung injury. This review
will discuss the progress, thus far, in the application of in vivo RNA interference-based gene therapy in the investigation of
inflammation-associated lung injury. (IJCEM801002).
Key Words: acute lung injury, inflammation, RNA interference, siRNA, gene silencing
Full Text PDF
Address all correspondence to: Dr. Joanne Lomas-Neira, Division of Surgical Research, Aldrich 244, Rhode Island Hospital, 593
Eddy Street, Providence, RI 02903, Tel: 401-444-7796, E-mail: jlomas@lifespan.org
Review Article
RNA Interference as A Potential Therapeutic Treatment for Inflammation Associated
Lung Injury
Joanne Lomas-Neira, Chun-Shiang Chung, Alfred Ayala
Division of Surgical Research, Department of Surgery, Rhode Island Hospital/Warren Alpert School of Medicine at Brown University,
Providence, RI 02903
Received January 3, 2008; accepted January 30, 2008; available online February 25, 2008
Abstract: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain important sources of morbidity for patients in
the ICUs in the developed world. However, imagine having as a therapeutic tool, the ability to regulate, in a tissue specific manner, the
expression of a given gene. RNA interference, as potentially such a method of selectively suppressing protein expression, has evolved
as an important tool in the study of gene specific function and targeted therapeutics. Significant progress has been made in identifying
potential gene targets integral to the pathways leading to the development of inflammation-associated lung injury. This review
will discuss the progress, thus far, in the application of in vivo RNA interference-based gene therapy in the investigation of
inflammation-associated lung injury. (IJCEM801002).
Key Words: acute lung injury, inflammation, RNA interference, siRNA, gene silencing
Full Text PDF
Address all correspondence to: Dr. Joanne Lomas-Neira, Division of Surgical Research, Aldrich 244, Rhode Island Hospital, 593
Eddy Street, Providence, RI 02903, Tel: 401-444-7796, E-mail: jlomas@lifespan.org
