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Int J Clin Exp Med 2013;6(4):294-297
Brief Communication
Alterations in prothrombin time and activated partial thromboplastin time in patients
with acute myocardial infarction
Haseeb A Khan, Abdullah S Alhomida, Tamader Y Al Rammah, Samia H Sobki, Mohammad S Ola, Adnan A Khan
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; College of Health and Rehabilitation
Sciences, Princess Nora Bint Abdulrahman University, Riyadh, Saudi Arabia; Division of Clinical Biochemistry, Department of
Pathology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
Received March 8, 2013; Accepted March 26, 2013; Epub April 12, 2013; Published April 30, 2013
Abstract: Prothrombin time (PT) and activated partial thromboplastin time (aPTT) respectively measures the extrinsic and intrinsic
pathways of coagulation and are used to determine the bleeding or clotting tendency of blood. We compared PT and aPTT levels in
acute myocardial infarction (AMI) patients and normal subjects. There were significant increases in PT levels in patients with STEMI
(15.98 ± 0.96 s), NSTEMI (16.03 ± 0.97 s) and chest pain (15.02 ± 0.54 s) as compared to control group (8.86 ± 0.08 s). The level of
aPTT in control subjects was 31.35 ± 0.48 s. Patients with STEMI (40.79 ± 1.83 s), NSTEMI (41.33 ± 2.06) and chest pain (37.84 ± 1.66
s) showed significantly higher levels of aPTT. There was a significant correlation between PT and aPTT levels. Both PT and aPTT were
significantly correlated with age however there was no correlation between these coagulation markers and gender or body mass index.
In conclusion, both PT and aPTT are significantly increased in AMI patients on anticoagulation therapy. The elevations in PT values
were more than 2.5-fold greater than aPTT suggesting a high potential of PT for predicting blood clotting tendency in patients receiving
anticoagulation therapy. (IJCEM1303006).
Keywords: Acute myocardial infarction, PT, aPTT, biomarker
Address correspondence to: Dr. Haseeb A Khan, Department of Biochemistry, College of Science, Bld 5, Rm 1B20, King Saud
University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. E-mail: khan_haseeb@yahoo.com, haseeb@ksu.edu.sa
Brief Communication
Alterations in prothrombin time and activated partial thromboplastin time in patients
with acute myocardial infarction
Haseeb A Khan, Abdullah S Alhomida, Tamader Y Al Rammah, Samia H Sobki, Mohammad S Ola, Adnan A Khan
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; College of Health and Rehabilitation
Sciences, Princess Nora Bint Abdulrahman University, Riyadh, Saudi Arabia; Division of Clinical Biochemistry, Department of
Pathology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
Received March 8, 2013; Accepted March 26, 2013; Epub April 12, 2013; Published April 30, 2013
Abstract: Prothrombin time (PT) and activated partial thromboplastin time (aPTT) respectively measures the extrinsic and intrinsic
pathways of coagulation and are used to determine the bleeding or clotting tendency of blood. We compared PT and aPTT levels in
acute myocardial infarction (AMI) patients and normal subjects. There were significant increases in PT levels in patients with STEMI
(15.98 ± 0.96 s), NSTEMI (16.03 ± 0.97 s) and chest pain (15.02 ± 0.54 s) as compared to control group (8.86 ± 0.08 s). The level of
aPTT in control subjects was 31.35 ± 0.48 s. Patients with STEMI (40.79 ± 1.83 s), NSTEMI (41.33 ± 2.06) and chest pain (37.84 ± 1.66
s) showed significantly higher levels of aPTT. There was a significant correlation between PT and aPTT levels. Both PT and aPTT were
significantly correlated with age however there was no correlation between these coagulation markers and gender or body mass index.
In conclusion, both PT and aPTT are significantly increased in AMI patients on anticoagulation therapy. The elevations in PT values
were more than 2.5-fold greater than aPTT suggesting a high potential of PT for predicting blood clotting tendency in patients receiving
anticoagulation therapy. (IJCEM1303006).
Keywords: Acute myocardial infarction, PT, aPTT, biomarker
Address correspondence to: Dr. Haseeb A Khan, Department of Biochemistry, College of Science, Bld 5, Rm 1B20, King Saud
University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. E-mail: khan_haseeb@yahoo.com, haseeb@ksu.edu.sa
