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Int J Clin Exp Med 2013;6(1):50-56
Original Article
Changes of acute-phase protein levels in the serum of lung cancer patients
following radiotherapy
Tolia G Maria, Kouloulias E Vasileios, Pantelakos S Panagiotis, Syrigos N Kostas
Department of Radiology, Radiation Oncology Unit, Medical School, Rimini 1, Haidari, Athens 12462, Greece; Radiation Oncology in
Medicine, Department of Radiology, Radiation Oncology Unit, Medical School, Rimini 1, Haidari, Athens 12462, Greece; Department of
Radiology, Radiation Oncology Unit, Medical School, Rimini 1, Haidari, Athens 12462, Greece; Oncology in Medicine, Oncology Unit,
Third Department of Medicine, University of Athens, Sotiria General Hospital, Mesogion 152 Avenue,115 27, Athens, Greece
Received September 17, 2012; accepted October 25, 2012; Epub November 18, 2012; Published January 1, 2013
Abstract: Purpose: the assessment of serum level changes of C-reactive protein (CRP), ferritin (FER), and albumin (ALB) as
inflammation markers in Non Small Cell Lung Cancer patients (stages ΙΙΙΑ – inoperable and stage ΙΙΙΒ) treated with radiotherapy.
Significant findings: Normal pre-radiotherapy levels of CRP were found in 18 patients, of FER in 17, and of ALB in 22. Higher levels of
CRP were found in 9 patients and of FER in 10. Lower ALB was found in 5 patients.Post-radiotherapy CRP levels were significantly
higher (compared to the pre-radiotherapy levels) in 25 patients. The same was observed regarding FER in 18 patients whereas 12
patients had lower post-radiotherapy levels. The statistical analysis (non parametrical Wilcoxon test) revealed that these differences
were statistically significant (p-value< 0.001). Conclusions: The levels of CRP, FER, and ALB are reliable and useful biomarkers
correlated with the acute complication of lung parenchyma damage induced by radiotherapy. (IJCM1209006).
Keywords: Acute phase proteins, lung cancer, radiotherapy
Address all correspondence to:
Dr. Tolia Maria
Consultant University Hospital
Attikon Athens Greece.
Tel.: +30-210-5831860; Fax: +30-210-5326418
E-mail: mariatolia1@gmail.com
Original Article
Changes of acute-phase protein levels in the serum of lung cancer patients
following radiotherapy
Tolia G Maria, Kouloulias E Vasileios, Pantelakos S Panagiotis, Syrigos N Kostas
Department of Radiology, Radiation Oncology Unit, Medical School, Rimini 1, Haidari, Athens 12462, Greece; Radiation Oncology in
Medicine, Department of Radiology, Radiation Oncology Unit, Medical School, Rimini 1, Haidari, Athens 12462, Greece; Department of
Radiology, Radiation Oncology Unit, Medical School, Rimini 1, Haidari, Athens 12462, Greece; Oncology in Medicine, Oncology Unit,
Third Department of Medicine, University of Athens, Sotiria General Hospital, Mesogion 152 Avenue,115 27, Athens, Greece
Received September 17, 2012; accepted October 25, 2012; Epub November 18, 2012; Published January 1, 2013
Abstract: Purpose: the assessment of serum level changes of C-reactive protein (CRP), ferritin (FER), and albumin (ALB) as
inflammation markers in Non Small Cell Lung Cancer patients (stages ΙΙΙΑ – inoperable and stage ΙΙΙΒ) treated with radiotherapy.
Significant findings: Normal pre-radiotherapy levels of CRP were found in 18 patients, of FER in 17, and of ALB in 22. Higher levels of
CRP were found in 9 patients and of FER in 10. Lower ALB was found in 5 patients.Post-radiotherapy CRP levels were significantly
higher (compared to the pre-radiotherapy levels) in 25 patients. The same was observed regarding FER in 18 patients whereas 12
patients had lower post-radiotherapy levels. The statistical analysis (non parametrical Wilcoxon test) revealed that these differences
were statistically significant (p-value< 0.001). Conclusions: The levels of CRP, FER, and ALB are reliable and useful biomarkers
correlated with the acute complication of lung parenchyma damage induced by radiotherapy. (IJCM1209006).
Keywords: Acute phase proteins, lung cancer, radiotherapy
Address all correspondence to:
Dr. Tolia Maria
Consultant University Hospital
Attikon Athens Greece.
Tel.: +30-210-5831860; Fax: +30-210-5326418
E-mail: mariatolia1@gmail.com
