 | |  | |  | |  | |  | |  | |  | |  |
| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2012;5(4):358-362
Case Report
Early-onset breast cancer in a woman with Graves’ disease
James E Siegler, Xinying Li, Steven D Jones, Emad Kandil
Tulane University School of Medicine; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China;
Department of Surgery, Tulane School of Medicine; Division of Endocrine and Oncological Surgery, Department of Surgery, Tulane
University School of Medicine, 1430 Tulane Ave. SL-22, New Orleans, LA 70112, USA.
Received April 4, 2012; accepted June 19, 2012; Epub August 22, 2012; Published September 15, 2012
Abstract: The relationship between thyroid and breast diseases has been documented, but the clinical significance of Graves’ disease
and breast cancer is unclear. We present a young patient with a history of Graves’ disease who developed a multicentric infiltrating
ductal carcinoma of the breast several months after discontinuing her treatment with propylthiouracil. Early-onset breast cancer in
women without a family history of early breast cancer may be related to hyperthyroidism. The relationship between thyroid hormone and
estrogen is discussed. (IJCEM1204004).
Keywords: Graves’ disease, thyroid hormone, estrogen, breast cancer
Address all correspondence to:
Dr. Emad Kandil
Division of Endocrine and Oncological Surgery
Department of Surgery, Tulane University School of Medicine
1430 Tulane Ave. SL-22, New Orleans, LA 70112, USA.
Tel: (504) 988-7407
E-mail: Ekandil@tulane.edu
Case Report
Early-onset breast cancer in a woman with Graves’ disease
James E Siegler, Xinying Li, Steven D Jones, Emad Kandil
Tulane University School of Medicine; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China;
Department of Surgery, Tulane School of Medicine; Division of Endocrine and Oncological Surgery, Department of Surgery, Tulane
University School of Medicine, 1430 Tulane Ave. SL-22, New Orleans, LA 70112, USA.
Received April 4, 2012; accepted June 19, 2012; Epub August 22, 2012; Published September 15, 2012
Abstract: The relationship between thyroid and breast diseases has been documented, but the clinical significance of Graves’ disease
and breast cancer is unclear. We present a young patient with a history of Graves’ disease who developed a multicentric infiltrating
ductal carcinoma of the breast several months after discontinuing her treatment with propylthiouracil. Early-onset breast cancer in
women without a family history of early breast cancer may be related to hyperthyroidism. The relationship between thyroid hormone and
estrogen is discussed. (IJCEM1204004).
Keywords: Graves’ disease, thyroid hormone, estrogen, breast cancer
Address all correspondence to:
Dr. Emad Kandil
Division of Endocrine and Oncological Surgery
Department of Surgery, Tulane University School of Medicine
1430 Tulane Ave. SL-22, New Orleans, LA 70112, USA.
Tel: (504) 988-7407
E-mail: Ekandil@tulane.edu
